There is much variability and no consensus on the definition of the most relevant outcome parameter after assisted reproduction technology (ART). Descriptive reports, such as annual statistics from national registries on the success of ART programmes, should present treatment success in terms of live birth per ovarian stimulation started, as this is the most relevant information for patients and doctors alike. Addressing concerns about the high rate of multiple pregnancies, rescaling the outcome of ART in large programmes and national audits to the singleton, live birth, might trigger a global change of attitude towards elective single embryo transfer in addition to any legal restrictions imposed. For clinical studies, the outcome measure will depend on the hypothesis tested, and investigators should remain free to choose the appropriate primary outcome measure.
(Abstracted from Human Reproduction 2018;33(9):1767–1776)
Preimplantation genetics for aneuploidy (PGT-A) has shown mixed results on pregnancy rates when applied at the cleavage stage of development due to a high rate of mosaicism and limitations of the comprehensive chromosomal screening technology, FISH, which was available at the time. A pilot study aiming to address this found that array comparative genomic hybridization (aCGH) analysis of both polar bodies possessed 94% concordance with the chromosome analysis of the resulting fertilized oocytes.
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