Background and aimsSARS-CoV-2 is a single-strained RNA virus belonging to Corona viridae's family. In paediatric age the majority of patients are asymptomatic, however several neurological manifestations associated with SARS-CoV-2 infection have been detected in a percentage of cases ranging from 17.3% to 36.4%. Acute Disseminated Encephalomyelitis (ADEM) has been recently included among the potential complications of SARS-CoV-2 infection. The available data regarding paediatric patient show only one case.
MethodsCase report: We present a case regarding a six-year-old child suffering from Fisher Evans Syndrome treated with Sirolimus and Thalidomide therapy and affected by SARS-CoV-2 infection.
ResultsCase report: We present a case regarding a six-year-old patient suffering from Fisher Evans Syndrome who was given Sirolimus and Thalidomide therapy. After ten days since the first positive nasopharyngeal swab for Sars-CoV-2, in which he had no symptoms, he presented an episode of generalized tonic-clonic seizure with spontaneous resolution. The patient underwent MRI which showed the typical picture of Acute Disseminated Encephalomyelitis. His clinical course was favourable, with a good response to cortisone therapy and a progressive improvement of the neuroradiological and electroencephalographic picture.
ConclusionsAccording to our knowledge, this is the second case of an Acute Disseminated Encephalomyelitis following SARS-CoV-2 infection in a paediatric patient, characterized by monosymptomatic onset, in which the immunosuppressive therapy practiced for the Fisher Evans Syndrome has probably contributed to a favourable evolution of ADEM, in contrast to other case described in the literature.
respiratory disease. The virus causing the infection has been namedsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Symptoms are mainly respiratory, around 40% may manifest with mild neurological symptoms.
MethodsMethods: We included 35 patients with SARS-CoV-2 infection hospitalized in Intensive Care Unit, with presentation of severe neurological events.
ResultsResults: Our hospital (San José, Tecnológico de Monterrey) has treated 2,920 patients infected by COVID19 in 1 year, 351 patients have required intubation, 1.19% have severe neurological manifestations and the reported mortality is 11.4%. This cohort includes 82% males, median age 57.9 (±14.96 years), first day of consultation by the neurology service was 22.21 (±19.8 days), most frequent neurological presentation was encephalitis in 31.4%. The rest of neurological events were 5.7% myasthenic crisis, 2.9% microangiopathy, 5.7% Guillain Barre syndrome, 11.4 % status epilepticus, 22. 9% STROKE, and around 20% presented Posterior reversible encephalopathy syndrome (PRES) and Autonomic dysfunction in 'long COVID'.
ConclusionsConclusion: Reports of severe neurological involvement in COVID-19 are increasing, which makes this problem particularly relevant to neurological critical care therapy. The nervous system can be directly or, more frequently, indirectly be involved. We anticipate that these neurological events will represent a large proportion of primary and secondary care consultations in coming months.
a lifetime depression frequency among people with FM was 65% (J.S. Løge-Hagena, et al., 2019). Additionally, fibromyalgia is more common in women (4.2%) than men (0.2%) (Mas, Carmona, Valverde, Ribas, & Group, 2008). This study aimed to investigate the prevalence of depression in patients with FM treated at the Neuro-Psychiatric Center in Riem (NPZR).
MethodsA total of 96 FM patients (19.8%, n = 19 male and 80.2%, n = 77 female) diagnosed with FM were selected from patient files between 2015 and 2021. Clinical interviews and the Beck Depression Inventory (BDI) had been conducted in FM patients to measure the level of depression.
ResultsThe sample showed a significant gender difference with 80.2% female patients, 49% of participants were between 51 and 60 years old. The study sample showed a high prevalence of severe depression (85.4%). Tinnitus, and migraine were the most common comorbidities (both 12.5%). 57.3% of patients enrolled in 2015 still continue their treatment.
ConclusionsThe ongoing research is in line with previous studies: FM patients are mainly female and older than 50 and demonstrate high levels of depression and comorbidities such as Tinnitus and Migraine.
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