During an investigation of the biological properties of certain polydiguanides it was found that bisdiguanides of the general type: aryl.NH.C(: NH).NH.C(: NH).NH.(CH2)n. NH.C.(: NH).NH.C(: NH).NH.ary1J exhibited marked antibacterial activity in vitro against a wide range of microorganisms , including Pseudomonas pyocyanea. Such bisdiguanides offered considerable scope for structural variation, and many substances of this kind were synthesized and tested (Table I) before it was ultimately decided that one compound, Serial No. 10,040, had the most outstanding bacteriostatic properties.
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