Background and Aim: It has long been known that the spermatogenic tissue is very sensitive to temperatures higher than its physiologic temperature and causing cessation of activity and resulting in sterility. This study investigated the effect of a standardized 40% ellagic acid extract of pomegranate on the histopathology, diameter, and epithelial thickness of seminiferous tubules in albino rats exposed to heat. Materials and Methods: Twenty-five male albino Wistar rats were randomized at 7-8 months of age to five treatment groups. Group C was not treated; Group T0 was treated with 0.5% of Na carboxymethyl cellulose (CMC) 2 ml/day and exposed to heat. T1, T2, and T3 were treated with 75, 150, and 300 mg/kg/day of a standardized 40% ellagic acid extract of pomegranate (Punica granatum L.), respectively. The animals were orally administered Na CMC or pomegranate extract and were exposed to sunlight for 15 min at 40°C-42°C for 14 days. The animals were sacrificed on day 15 and the testes were removed for histological evaluation and measurement of seminiferous tubule diameter and epithelium thickness. Results: The diameter of seminiferous tubules from rats exposed to heat and treated with 300 mg/kg/day pomegranate extract was larger and the epithelia thicker than those in the other groups (p= <0.05). The protective effects of the standardized 40% ellagic acid extract may have been mediated by its antioxidant activity. Conclusion: Compared with controls, administration of 300 mg/kg/day of a standardized 40% ellagic acid extract of P. granatum L. for 14 days increased seminiferous tubule diameter and epithelium thickness in albino Wistar rats exposed to heat. Keywords: diameter, epithelium thickness, heat, pomegranate extract, seminiferous tubule.
Aim: This study aimed to determine the potential of honey as anti-osteoporosis by evaluating its effectiveness in increasing bone impact strength and cortical thickness, through scanning electron microscopy (SEM) examination. Materials and Methods: Forty-five female rats at 3 months of age, weighing 150-200 g were used in the study. They were placed in individual cages and adapted to food and environment for 10 days. On the 11th day, after the animals were adapted for 10 days, the animals were randomly divided into five treatment groups (n=9): Sham operation group (SH); ovariohysterectomized (OVX) group with no treatment; OVX with treatment Apis dorsata 1 g/kg BW (AD-1); OVX with treatment A. dorsata 2 g/kg BW (AD-2); and OVX with treatment A. dorsata 4 g/kg BW (AD-3). Furthermore, those nine rats in each treatment group were divided into three groups. Three of them were observed at months 1st, 2nd, and 3rd so that in each observation taken three rats in each treatment group. At the end of the study, the rats were euthanized and necropsy for taking their second femoral bone, i.e. dexter region for examining their bone impact strength, while the sinister region was used for measure the cortical thickness of the femoral diaphysis and examining their bone microarchitecture using SEM analysis. Results: Based on results of the ANOVA test, the cortical thickness measurements of femoral diaphyseal can be seen that from month 1 to month 3 the lowest result was found in the group of rats that were OVX-I. Meanwhile, the highest result was found in the group of rats that were not OVX (SH-III). It was significantly different from the other treatment groups (p<0.05). The groups of rats were OVX with honey supplementation at doses of 2 g/kg BW had shown an increasing pattern in the cortical bone thickness from month 1 to month 3. Even on the observation of the 3rd month, the cortical bone thickness in the AD-2 (AD-2-III) group was not significantly different (p>0.05) from that in the group of rats was not OVX in month 1 (SH-I). The results of the bone impact strength measurement from month 1 to month 3 indicated that the groups of rats were OVX without the administration of honey supplements had the lowest value. The highest bone impact strength was found in the group of rats that was not OVX, but not significantly different (p>0.05) with the groups of rats that were OVX administered honey supplement with a dose of 2 g/kg BW (AD-2) and 4 g/kg BW (AD-3). Conclusion: The supplement of honey A. dorsata at doses of 2 g/kg BW in the group of rats was that OVX can inhibit the decreasing of the cortical bone thickness and repair damage in microarchitecture to generate bone impact strength. As a result, bones are not easily broken.
Jalur Lingkar Wilis is a road which is connecting six cities in East Java Province, throughout Nganjuk, Ponorogo, Madiun, Tulungagung, Trenggalek, and Kediri. This road was placed along the foothill of Wilis Mountain which is this location was part of a protected forest and located in Geger Village, Sendang Sub – District. Therefore, some parts of protected forests face deforestation as the consequence of the Jalur Lingkar Wilis construction. This deforestation made the total of trees in Wilis Mountain decrease to worried conditions and cause the water absorption area in Tulungagung also fall on decreation. According to this condition, it takes awareness from all of the stakeholders to maintain the water absorption area through reforestation. This activity is in collaboration between Universitas Airlangga students with Perhutani, KPHLS Sendang, and Tulungagung Society to prepare and execute this reforestation. By the reforestation 220 trees were planted along the Jalur Lingkar Wilis. The reforestation is expected to prevent the protected forest area in Wilis Mountain from environmental damage as the consequence of Jalur Lingkar Wilis construction and also protect the water availability in Tulungagung.abstrakJalur Lingkar Wilis adalah jalur yang menghubungkan enam kabupaten di Jawa Timur, mulai dari Kabupaten Nganjuk, Ponorogo, Kabupaten Madiun, Tulungagung, Trenggalek, dan Kediri. Jalur ini melewati daerah kaki Gunung Wilis yang merupakan daerah hutan lindung yang terletak di Desa Geger, Kecamatan Sendang. Hal ini membuat sebagian wilayah dari hutan lindung harus mengalami penggundulan sebagai konsekuensi dari pembangunan Jalur Lingkar Wilis. Sehingga pohon-pohon di sekitar Jalur Lingkar Wilis mengalami penurunan jumlah yang mengkhawatirkan. Permasalahan tersebut menyebabkan daerah resapan air di Kabupaten Tulungagung mengalami penurunan, sehingga diperlukan kesadaran semua pihak untuk mengembalikan dan mempertahankan daerah resapan air dengan cara reboisasi. Kegiatan ini merupakan kerjasama mahasiswa Universitas Airlangga dengan Perhutani, KPHLS Tulungagung, dan Tulungagung Society. Hasil dari kegiatan reboisasi ini tertanam sejumlah 220 bibit pohon pule, petai, nangka, dan alpukat di sepanjang Jalur Lingkar Wilis. Adanya kegiatan ini diharapkan wilayah hutan lindung kaki Gunung Wilis terhindar dari kerusakan akibat pembangunan Jalur Lingkar Wilis dan ketersediaan air di Kabupaten Tulungagung terus terjaga.
Tuban Regency applies a concept of an efficient livestock business considering that there are many potentials and opportunities that have not been utilized and managed optimally. Parengan Subdistrict is one of the areas in Tuban Regency with high potential for beef cattle and goats. The increase in the price of chemical fertilizers followed by restrictions on subsidized fertilizer quotas is the main problem of these communities. The potential raw materials that can be used to make organic fertilizers are available quite a lot in the area. The implementation of the PKM Community Service is carried out by approaching methods to solve partner problems. Community empowerment, especially breeders, is directed at activities to increase competitiveness and community participation through increasing the capacity and institutionalization of farmer human resources with various socialization counseling and training on making organic fertilizer for ruminant waste as a substitute for chemical fertilizers. The results achieved are in the form of improving the skills and knowledge of partners to process ruminant waste into organic fertilizer. Key words: Cow; Goat; Manure; Organic; Ruminant
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