Where the sudden increase in MIC of a culture occurs during or after therapy. Antibiotic tolerance is known as a phenomenon where the Minimum Bactericidal Concentration (MBC) and MIC is very large [4]. Resistance mechanisms preexist or are modifi ed by nature, either by transfer of resistance genes or by mutations, which can be localized in the bacterial chromosome or in plasmids [1]. There are several mechanisms of bacterial resistance, such as; enzymatic inactivation, reduced intracellular accumulation due to the action of effl ux pumps, the presence of transposons, resistance plasmids, and the capacity for transduction, transformation and conjugation [5]. The dissemination of genetic knowledge corroborates the rapid implementation of the management plan on the treatment of the various types of resistant infections, previous knowledge favors to avoid administration of antibiotics in a widespread and indiscriminate way. Methodology Published articles, technical manuals describing the different types of genes, plasmids and/or resistance markers to there is a gradual increase of the Minimum Inhibitory Concentration (MIC) over time. In order to have a therapeutic effect it is necessary to achieve adequate serum and tissue
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