Evolution occurs in populations of reproducing individuals. The structure of a population can affect which traits evolve. Understanding evolutionary game dynamics in structured populations remains difficult. Mathematical results are known for special structures in which all individuals have the same number of neighbours. The general case, in which the number of neighbours can vary, has remained open. For arbitrary selection intensity, the problem is in a computational complexity class that suggests there is no efficient algorithm. Whether a simple solution for weak selection exists has remained unanswered. Here we provide a solution for weak selection that applies to any graph or network. Our method relies on calculating the coalescence times of random walks. We evaluate large numbers of diverse population structures for their propensity to favour cooperation. We study how small changes in population structure-graph surgery-affect evolutionary outcomes. We find that cooperation flourishes most in societies that are based on strong pairwise ties.
We prove the Li-Yau gradient estimate for the heat kernel on graphs. The only assumption is a variant of the curvature-dimension inequality, which is purely local, and can be considered as a new notion of curvature for graphs. We compute this curvature for lattices and trees and conclude that it behaves more naturally than the already existing notions of curvature. Moreover, we show that if a graph has nonnegative curvature then it has polynomial volume growth.We also derive Harnack inequalities and heat kernel bounds from the gradient estimate, and show how it can be used to strengthen the classical Buser inequality relating the spectral gap and the Cheeger constant of a graph.
The spatial structure of an evolving population affects which mutations become fixed. Some structures amplify selection, increasing the likelihood that beneficial mutations become fixed while deleterious mutations do not. Other structures suppress selection, reducing the effect of fitness differences and increasing the role of random chance. This phenomenon can be modeled by representing spatial structure as a graph, with individuals occupying vertices. Births and deaths occur stochastically, according to a specified update rule. We study death-Birth updating: An individual is chosen to die and then its neighbors compete to reproduce into the vacant spot. Previous numerical experiments suggested that amplifiers of selection for this process are either rare or nonexistent. We introduce a perturbative method for this problem for weak selection regime, meaning that mutations have small fitness effects. We show that fixation probability under weak selection can be calculated in terms of the coalescence times of random 1 arXiv:1906.01036v1 [q-bio.PE] 3 Jun 2019 walks. This result leads naturally to a new definition of effective population size. Using this and other methods, we uncover the first known examples of transient amplifiers of selection (graphs that amplify selection for a particular range of fitness values) for the death-Birth process. We also exhibit new families of "reducers of fixation", which decrease the fixation probability of all mutations, whether beneficial or deleterious.
Abstract. In 2008 Nguyen and Onak constructed the first constant-time algorithm for the approximation of the size of the maximum matching in bounded degree graphs. The Borel oracle machinery is a tool that can be used to convert some statements in Borel graph theory to theorems in the field of constant-time algorithms. In this paper we illustrate the power of this tool to prove the existence of the above mentioned constant-time approximation algorithm.
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