Background: Sepsis is the most common cause of death in neonates worldwide. Coagulase- negative staphylococci (CoNS) are now the leading cause of nosocomial bacteremia in most pediatric hospitals. This study is done to speciate various CoNS isolated from neonatal sepsis cases and determine their antibiotic sensitivity prole Methods: 75 cases of neonatal sepsis with CoNS bacteremia (from single BacT/ ALERT PF bottle) formed the study group. The clinical isolates of CoNS were identied and their antibiograms determined by Vitek 2 system. MRCoNS were conrmed by mec A gene detection using conventional Uniplex PCR. Results: Among the CoNS isolates S. epidermidis accounted for 28% followed by S. hominis 27%, and S. lentus(26%), S. haemolyticcus (11%), S. saprophyticus (6%), S. warneri (2%). All the isolates were sensitive to vancomycin & linezolid (100%). Followed by tetracycline 81%, cotrimoxazole 80%, gentamycin 64%. 79% of the isolates were methicillin resistant and had mecA gene. Conclusion: The study concludes that, all the CoNS isolated from neonatal sepsis may be speciated and sensitivity patterns determined for better management of cases. Emergence Methicillin resistant Coagulase negative staphylococci is an important nosocomial pathogens mainly in neonatal intensive care units was observed in this study.
Case Findings: A 55yr male patient presented with complaints of pain abdomen, vomiting, constipation, & weight loss. Aim And Objectives:To isolate the causative agent, empiric therapy and antibiogram. Methods: Ascitic fluid was sent for grams stain & culture sensitivity. The fluid was centrifuged and the sediment used for making grams stain & processed according to the standard protocols Result:The organism was identified as Enterococcus faecalis and antibiogram obtained which was sensitive to Quinolones. Conclusion:There is an increasing prevalence of enterococcal spontaneous bacterial peritonitis associated with poor prognosis due to multidrug resistance when inappropriately treated. So, the clinicians should consider empirical treatment with anti-enterococcal antibiotics.
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