Peritoneal carcinomatosis is a common clinical situation followed by a 4-5-day course of ganciclovir treatment, that requires novel therapeutic approaches. We investishowed an increased survival as compared with control gated the efficiency of an HSVtk gene therapy for the treatrats and with those treated with a single cycle of retrovirus ment of peritoneal carcinomatosis induced in syngeneic producing cells plus ganciclovir. However, only a few anirats by DHD/K12 colon carcinoma cells. In this setting, the mals remained tumor-free after day 180. There was no difefficiency of two different retrovirus producing cell lines ference between the two producing cell lines in any of the (GP+AmEnv12 and FLYA13) was compared. Rats treated experiments. RT-PCR demonstrated a faint expression of with a single injection of retrovirus producing cells followed the tk transgene in the liver, spleen, epiploon, bowels and by a 5-day course of ganciclovir treatment showed an the lung of the animals injected with the HSVtk producing increased survival as compared with control animals. Anicells, reflecting most likely the transduction of only a limited mals treated with three injections of producing cells, each number of cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.