In this study, the dissociation constants of a series of phenolic acids, including benzoic acid, four hydroxylated derivatives (p-hydroxybenzoic, protocatechuic, vanillic, and gallic), and four hydroxylated cinnamic acid derivatives (p-coumaric, caffeic, ferulic, and sinapinic) have been determined in water by capillary electrophoresis (CE) from the electrophoretic mobilities at different pH value. The pK
a values have also been obtained from the absorbance spectra at the maximum of the electrophoretic peaks, which were measured with a diode-array detector (CE-DAD methodology). The pK
a values obtained from both methodologies (CE and CE-DAD) have been compared with those previously published in the literature and also with the values predicted by the SPARC online pK
a calculator.
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