The time evolution of the axial velocity of a metastable Xe + ion was examined in the crossed-field discharge of a PPS100-ML Hall thruster fired at 250 V by means of laser-induced fluorescence spectroscopy at 834.72 nm. A pulse-counting detection technique was employed to achieve a time resolution of 0.1 µs. A periodic break of 10 µs duration of the anode current is used to stabilize the discharge and allow the investigation of both forced and natural plasma oscillations. Measurements were carried out along the channel axis throughout the region of large magnetic field strength. The mean ion flow velocity was found to oscillate at the discharge breathing mode frequency of about 21 kHz. By contrast, the ion velocity dispersion appears not to depend on time, which suggests a strong correlation between ionization and acceleration processes. The spatio-temporal behavior of the electric field was computed from experimental data using a Lagrangian description of the ion fluid motion. As expected, the field amplitude varies significantly at 21 kHz. More surprisingly, an electric field front seems to propagate periodically from the exterior toward the interior of the discharge chamber with a speed close to the thermal speed of the Xe atom.

A fraction of HIV is associated with erythrocytes even when the virus becomes undetectable in plasma under antiretroviral therapy. The aim of the present work was to further characterize this association in vitro. We developed an in vitro model to study the factors involved in the adherence of HIV-1 to erythrocytes. Radiolabeled HIV-1 (HIV) and preformed HIV-1/anti-HIV immune complexes (HIV-IC) were opsonized in various human sera, purified using sucrose density gradient ultracentrifugation, and incubated with human erythrocytes. We observed that, when opsonized in normal human serum, not only HIV-IC, but also HIV, bound to erythrocytes, although the adherence of HIV was lower than that of HIV-IC. The adherence was abolished when the complement system was blocked, but was maintained in hypogammaglobulinemic sera. Complement-deficient sera indicated that both pathways of complement were important for optimal adherence. No adherence was seen in C1q-deficient serum, and the adherence of HIV was reduced when the alternative pathway was blocked using anti-factor D Abs. The adherence could be inhibited by an mAb against complement receptor 1. At supraphysiological concentrations, purified C1q mediated the binding of a small fraction of HIV and HIV-IC to erythrocytes. In conclusion, HIV-IC bound to erythrocytes as other types of IC do when exposed to complement. Of particular interest was that HIV alone bound also to erythrocytes in a complement/complement receptor 1-dependent manner. Thus, erythrocytes may not only deliver HIV-IC to organs susceptible to infection, but free HIV as well. This may play a crucial role in the progression of the primary infection.

Phase change memory can provide a remarkable artificial synapse for neuromorphic systems, as it features excellent reliability and can be used as an analog memory. However, this approach is complicated by the fact that crystallization and amorphization differ radically: crystallization can be realized in a very gradual manner, very similarly to synaptic potentiation, while the amorphization process tends to be abrupt, unlike synaptic depression. Addressing this non‐biorealism of amorphization requires system‐level solutions that have considerable energy cost or limit the generality of the approach. This work demonstrates experimentally that an adaptation of the memory structure associated with an initialization electrical pulse followed by a sequence of identical fast pulses can overcome this challenge. A single device can then naturally implement gradual long‐term potentiation and depression, much like synapses in biology. This study evidences through statistical measurements the reproducibility of the approach, discusses its physical origin, as well as the importance of the device architecture and of the initial electrical pulse. Through the use of system‐level simulation, it is shown that this device is especially adapted to a neuroscience‐inspired learning. These results highlight how nanodevices can be suitable for bioinspired applications while retaining the qualities of industrial technology.