Massive antenna arrays can be used to meet the requirements of 5G, by exploiting different spatial signatures of users. This same property can also be harnessed to determine the locations of those users. In order to perform massive MIMO localization, refined channel estimation routines and localization methods have been developed. This paper provides a brief overview of this emerging field.
Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and this is quite different from the common cell death patterns such as apoptosis, pyroptosis, necroptosis, and ferroptosis. Interestingly, like with death patterns, cuproptosis-related genes have recently been reported to regulate the occurrence and progression of various tumors. However, in bladder cancer, the link between cuproptosis and clinical outcome, tumor microenvironment (TME) modification, and immunotherapy is unknown. To determine the role of cuprotosis in the tumor microenvironment, we systematically examined the characteristic patterns of 10 cuproptosis-related genes in bladder cancer (BLCA). By analyzing principal component data, we established a cuproptosis score to determine the degree of cuproptosis among patients. Finally, we evaluated the potential of these values in predicting BLCA prognosis and treatment responses. A comprehensive study of the mutations of cuproptosis-related genes in BLCA specimens was conducted at the genetic level, and their expression and survival patterns were evaluated using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Two cuproptosis patterns were constructed based on the transcription level of 10 cuproptosis-related genes, featuring differences in the prognosis and the infiltrating landscape of immune cells (especially T and dendritic cells) with interactions between cuproptosis and the TME. Our study further demonstrated that cuproptosis score may predict prognosis, immunophenotype sensitivity to chemotherapy, and immunotherapy response among bladder cancer patients. The development and progression of bladder cancer are likely to be influenced by cuproptosis, which may involve a diverse and complex TME. The cuproptosis pattern evaluated in our study may enhance understanding of immune infiltrations and guide more potent immunotherapy interventions.
In global mobility networks, anonymous user authentication is an essential task for enabling roaming service. In a recent paper, Jiang et al. proposed a smart card based anonymous user authentication scheme for roaming service in global mobility networks. This scheme can protect user privacy and is believed to have many abilities to resist a range of network attacks, even if the secret information stored in the smart card is compromised. In this paper, we analyze the security of Jiang et al.'s scheme, and show that the scheme is in fact insecure against the stolen-verifier attack and replay attack. Then, we also propose a new smart card based anonymous user authentication scheme for roaming service. Compared with the existing schemes, our protocol uses a different user authentication mechanism, which does not require the home agent to share a static secret key with the foreign agent, and hence, it is more practical and realistic. We show that our proposed scheme can provide stronger security than previous protocols.
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