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The therapeutic results achieved in the treatment of anetoderma of Jadassohn with ε-aminocaproic acid is reported, which constitutes the first case in the literature which produced a permanent cure. Although the mechanism of action of ε-aminocaproic acid is not clear, the indisputable disappearance of the erythematous plaques and the subsequent prevention of the development of herniated lesions and bag-like protrusions are clear evidence of the therapeutic efficacy of this drug. Because an inflammatory process preceded these lesions, which was suppressed by the administration of ε-aminocaproic acid, the possibility is assumed that this anti-fibrinolytic drug may act by indirectly diminishing the amount of activity of the inflammatory peptides bradykinin, or similar substances.

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