The role of endoplasmic reticulum (ER)-stress proteins in the pathogenesis of neoplasia remains obscure. ERp29 encodes for an ER protein that is thought to facilitate the transport of secretory proteins in the early secretory pathway. ERp29 is expressed at varying levels in virtually every tissue tested, yet its precise role remains obscure. To test if ERp29 is associated with the pathogenesis of skin cancer, in the present study we have assessed the expression of ERp29 in basal-cell carcinoma of the skin. A bank of 104 basal skin carcinoma, including 50 nodular, 29 infiltrating, 15 superficial, 7 sclerosing, 2 fibroepithelial, and 1 pigmented cell carcinoma, were assessed by immunohistochemistry for ERp29 expression. Thirty-nine (37.5%) of the samples tested expressed ERp29 with the infiltrating carcinomas displaying more intense (++,+++) immunoreactivity (6/29, P < 0.05) and the superficial carcinomas exhibiting the less intense anti-ERp29 staining (1/15, P < 0.05). Collectively our results suggest that ERp29 is expressed in a subset of basal-cell carcinoma of the skin with the infiltrating carcinomas exhibiting the highest incidence of immunopositivity. The role of ERp29 in the pathogenesis of the disease and its potential diagnostic value should be explored in future investigations.
Is territory a trap? Does the concept of territory trap us into false assumptions of internally homogeneous, externally bounded political communities that exercise uniform sovereignty across their domain? Against the background of debates about territory and the territorial state in international relations, this symposium brings together five contributions in political theory that advance a nuanced and systemic understanding of what territory is. Taken together, they indicate that there is much to the territorial paradigm beyond the modern, sovereign, and territorial state model. There are diverse conceptions of territory, which may be relevant across different legal and political orders. The various conceptual analyses of territory in this symposium suggest that the sovereign state model is only one way in which a sovereign political authority can be territorial. These essays provide the conceptual tools to formulate (and subsequently test) the hypothesis that the transformations in statehood may not be best described in terms of the rise and decline of territorial sovereignty, but as moves from one model of territorially bounded political authority to another. In political theory, it is only in recent years that this foundational concept has received sustained attention from political theorists. This symposium aims to take forward this welcome theoretical development.
Inhabitants of low-lying islands flooded due to anthropogenic climate change will lose their territory and thereby their ability to exercise their right to political self-determination. This paper addresses the normative questions which arise when climate change threatens territorial rights. It explores whether the loss of statehood supports a claim to territorial compensation, and if so, how it can be satisfied. The paper concludes that such claims are well founded and that they should be met by providing compensatory territories. After introducing a differentiation between land rights and territorial rights, previous theoretical responses to the problem of sinking islands are criticized. It is argued that states may be required to give up parts of their territory as compensation. The paper develops criteria of sufficiency for compensatory territories and proposes to base their selection process on a negative auction. Since it is unlikely that unsettled compensatory territories that meet the specified requirements are available, the rights of their original inhabitants are discussed.
We recommend diagnostic arthroscopy with assessment of stability prior to the open performance to offer a more reliable evidence for surgical technique selection and therefore to achieve a better clinical outcome.
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