Mechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN, which can be trapped and incorporated into α-aminonitriles. This prebiotic impact scenario can be extended by mechanochemically transforming the resulting α-aminonitriles into α-amino amides using a chemical route related to early Earth conditions.
Mechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN,w hich can be trapped and incorporated into a-aminonitriles.T his prebiotic impact scenario can be extended by mechanochemically transforming the resulting a-aminonitriles into a-amino amides using ac hemical route related to early Earth conditions.Scheme 2. Mechanosynthesis of a-aminonitriles 3 using K 3 [Fe(CN) 6 ]. [23] Scheme 3. Mechanochemical hydration of 3aa.
Under mechanochemical conditions in ball mills, copper-and vanadium-containing minerals initiate atom transfer radical cyclizations and oxidative couplings, respectively. Only catalytic quantities of the minerals are required, and the reactions proceed either under neat conditions or in the presence of a minimal amount of solvent.
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