Deltas are resource rich, low-lying areas where vulnerability to flooding is exacerbated by natural and anthropogenically induced subsidence and geocentric sea-level rise, threatening the large populations often found in these settings. Delta 'drowning' is potentially offset by deposition of sediment on the delta surface, making the delivery of fluvial sediment to the delta a key balancing control in offsetting relative sea-level rise, provided that sediment can be dispersed across the subaerial delta. Here we analyse projected changes in fluvial sediment flux over the 21st century to 47 of the world's major deltas under 12 environmental change scenarios. The 12 scenarios were constructed using four climate pathways (Representative Concentration Pathways 2.6, 4.5, 6.0 and 8.5), three socioeconomic pathways (Shared Socioeconomic Pathways 1, 2 and 3), and one reservoir construction timeline. A majority (33/47) of the investigated deltas are projected to experience reductions in sediment flux by the end of the century, when considering the average of the scenarios, with mean and maximum declines of 38% and 83%, respectively, between 1990-2019 and 2070-2099. These declines are driven by the effects of anthropogenic activities (changing land management practices and dam construction) overwhelming the effects of future climate change. The results frame the extent and magnitude of future sustainability of major global deltas. They highlight the consequences of direct (e.g. damming) and indirect (e.g. climate change) alteration of fluvial sediment flux dynamics and stress the need for further in-depth analysis for individual deltas to aid in developing appropriate management measures.

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Recombinant baculoviruses were used to produce human B19 parvovirus empty capsids composed of only VP2 and VP2 capsids containing 4%, 25%, 35%, or 41% VP1 protein. Immunogenicity of the purified capsids, formulated with or without adjuvant, was evaluated in mice, guinea pigs, and rabbits. Sera were analyzed for total anti-B19 parvovirus antibodies, antibodies specific to the region unique to the VP1 capsid protein, and virus neutralizing antibodies. A relationship was observed between the development of antibodies specific to sequences unique to the VP1 protein and virus neutralization. The polypeptide composition of the empty capsid immunogens appeared to be important for elicitation of potent virus neutralizing activity. VP2 capsid immunogens devoid of VP1 protein, or consisting of only 4% VP1, the composition of naturally occurring virions, were generally poor at eliciting high levels of virus neutralizing activity. Capsids consisting of > or = 25% VP1 protein efficiently and consistently provoked vigorous B19 virus neutralizing responses. Recombinant empty capsids enriched for the VP1 protein should serve as the basis for a human B19 parvovirus vaccine.

We employ a climate-driven hydrological water balance and sediment transport model (HydroTrend) to simulate future climate-driven sediment loads flowing into the Ganges-Brahmaputra-Meghna (GBM) mega-delta. The model was parameterised using high-quality topographic data and forced with daily temperature and precipitation data obtained from downscaled Regional Climate Model (RCM) simulations for the period 1971-2100. Three perturbed RCM model runs were selected to quantify the potential range of future climate conditions associated with the SRES A1B scenario. Fluvial sediment delivery rates to the GBM delta associated with these climate data sets are projected to increase under the influence of anthropogenic climate change, albeit with the magnitude of the increase varying across the two catchments. Of the two study basins, the Brahmaputra's fluvial sediment load is predicted to be more sensitive to future climate change. Specifically, by the middle part of the 21(st) century, our model results suggest that sediment loads increase (relative to the 1981-2000 baseline period) over a range of between 16% and 18% (depending on climate model run) for the Ganges, but by between 25% and 28% for the Brahmaputra. The simulated increase in sediment flux emanating from the two catchments further increases towards the end of the 21(st) century, reaching between 34% and 37% for the Ganges and between 52% and 60% for the Brahmaputra by the 2090s. The variability in these changes across the three climate change simulations is small compared to the changes, suggesting they represent a significant increase. The new data obtained in this study offer the first estimate of whether and how anthropogenic climate change may affect the delivery of fluvial sediment to the GBM delta, informing assessments of the future sustainability and resilience of one of the world's most vulnerable mega-deltas. Specifically, such significant increases in future sediment loads could increase the resilience of the delta to sea-level rise by giving greater potential for vertical accretion. However, these increased sediment fluxes may not be realised due to uncertainties in the monsoon related response to climate change or other human-induced changes in the catchment: this is a subject for further research.