A systematic study on hippuric acid substituents was performed in order to better understand the influence of stereoelectronic factors on the Erlenmeyer reaction rate. In addition, two reaction systems were evaluated: Hünig’s base solvent free conditions and catalytic sodium acetate in 2-methyl-THF. The effect on reaction rate of electron withdrawing and electron donating groups are reported. Specifically, the study led to the conclusion that stereoelectronic factors have significant influence in one of our key Erlenmeyer reaction by affecting its reaction rate.
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A Practical and Efficient Synthesis of 2,5-Disubstituted-3,5-dihydro-imidazol--4-ones from Oxazolones. -A practical and efficient method for the synthesis of 2,5-disubstituted-3,5-dihydro-imidazol-4-ones (II) is developed. Ammonium carbamate is found to be an excellent source of ammonia at the initiatory oxazolone ring-opening step. The subsequent imidazolone cyclization can be achieved in the presence of K 2 CO 3 or DBU. The procedure is suitable for scaling up to supply gram quantities. -(CHAVEZ*, F.; PAVY, C.; WILLIAMSON, T.; CLEARY, T.; Synth. Commun. 42 (2012) 22, 3321-3327, http://dx.
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