Bat algorithm is a population metaheuristic proposed in 2010 which is based on the echolocation or bio-sonar characteristics of microbats. Since its first implementation, the bat algorithm has been used in a wide range of fields. In this paper, we present a discrete version of the bat algorithm to solve the well-known symmetric and asymmetric traveling salesman problems. In addition, we propose an improvement in the basic structure of the classic bat algorithm. To prove that our proposal is a promising approximation method, we have compared its performance in 37 instances with the results obtained by five different techniques: evolutionary simulated annealing, genetic algorithm, an island based distributed genetic algorithm, a discrete firefly algorithm and an imperialist competitive algorithm. In order to obtain fair and rigorous comparisons, we have conducted three different statistical tests along the paper: the Student's ttest, the Holm's test, and the Friedman test. We have also compared the convergence behaviour shown by our proposal with the ones shown by the evolutionary simulated annealing, and the discrete firefly algorithm. The experimentation carried out in this study has shown that the presented improved bat algorithm outperforms significantly all the other alternatives in most of the cases.

Noscapine and its 7-hydroxy and 7-amino derivatives were characterized for their binding to tubulin. A solution NMR structure of these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete for the same binding site nor does its small molecule crystal structure match its tubulin-bound conformation. These compounds were also tested for their antiproliferative effects on a panel hepatocellular carcinoma cell lines.

In this paper we show an instance-based reasoning e-mail filtering model that outperforms classical machine learning techniques and other successful lazy learners approaches in the domain of anti-spam filtering. The architecture of the learning-based anti-spam filter is based on a tuneable enhanced instance retrieval network able to accurately generalize e-mail representations. The reuse of similar messages is carried out by a simple unanimous voting mechanism to determine whether the target case is spam or not. Previous to the final response of the system, the revision stage is only performed when the assigned class is spam whereby the system employs general knowledge in the form of metarules.

A real-world newspaper distribution problem with recycling policy is tackled in this work. In order to meet all the complex restrictions contained in such a problem, it has been modeled as a rich vehicle routing problem, which can be more specifically considered as an asymmetric and clustered vehicle routing problem with simultaneous pickup and deliveries, variable costs and forbidden paths (AC-VRP-SPDVCFP). This is the first study of such a problem in the literature. For this reason, a benchmark composed by 15 instances has been also proposed. In the design of this benchmark, real geographical positions have been used, located in the province of Bizkaia, Spain. For the proper treatment of this AC-VRP-SPDVCFP, a discrete firefly algorithm (DFA) has been developed. This application is the first application of the firefly algorithm to any rich vehicle routing problem. To prove that the proposed DFA is a promising technique, its performance has been compared with two other well-known techniques: an evolutionary algorithm and an evolutionary simulated annealing. Our results have shown that the DFA has outperformed these two classic meta-heuristics.