Introdução: O câncer colorretal (CCR) é a terceira neoplasia mais comum no mundo e apresenta altas taxas de mortalidade. A pesquisa de sangue oculto nas fezes (PSOF) é um método de rastreamento simples, não invasivo e validado para rastreamento do CCR. Objetivo: Avaliar os diferentes métodos de PSOF, suas taxas de positividade ao longo dos anos e aderência individual ao exame. Metodologia: Trata-se de estudo transversal retrospectivo que avaliou todos os registros de PSOF realizadas em um laboratório de 2005 a 2019. Os pacientes foram agrupados por faixa etária e sexo e a taxa de positividade foi analisada. A PSOF foi feita em duas etapas até 2015: triagem com guáiaco e, se positivo, confirmava-se o resultado com imunoquímico. Desde 2016, todas as PSOF foram realizadas com o imunoquímico. A amostra final foi de 316,287 exames de 136,735 pacientes. Resultados: 68% dos exames foram realizados em mulheres. Homens tiveram mais resultados positivos (p < 0.001). Houve diferença significativa nas taxas de positividade até 2015 e de 2016 a 2019, quando o único método realizado foi o imunoquímico (1.3% vs. 10.0%; p < 0.001). A proporção de resultados positivos aumentou significativamente com a realização de mais de uma amostra e de mais exames
Objective: This study aimed to assess vitamin D (25OHD) levels in individuals who underwent an examination at a private laboratory (between latitudes 14º and 22º south) over 14 years, stratified by sex, age, and epidemiological profiles, and determine variations in the number of tests performed over the years. Materials and methods: All records of 25OHD tests performed at a private clinical laboratory in Brazil were analyzed. This retrospective cross-sectional study included patients stratified by sex (female or male), age range (0-17, 18-40, 41-59, and ≥ 60 years), and year of testing. The final sample size was 193,725 patients. Categorical variables are presented as absolute and relative frequencies and numerical variables as means ± standard deviation. Comparisons between groups were performed using the equality of proportions test. Results: The number of tests performed steeply increased since 2010. More tests were performed in female individuals (73.3%) and individuals aged 41-59 years (32.2%). Most samples (68.0%) demonstrated sufficient vitamin D status. Women had a higher incidence of vitamin D deficiency than men (33.1% and 26.6%, respectively; p < 0.001). Individuals aged ≥ 60 years had the highest incidence of vitamin D deficiency (68.4%), while individuals aged 0-17 years had the lowest (32.2%) (p < 0.001). Conclusion: Despite increased testing and attention given to vitamin D in recent years, our study demonstrates high levels of deficiency in a country with geographical conditions favorable to its production.
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