Photodynamic
therapy (PDT) and fluorescence imaging offer the possibility
of precise and personalized treatment of cancer, but low singlet oxygen
production of a commercial photosensitizer and the quenching effect
of fluorescent dyes limit the further application of PDT treatment
and fluorescence imaging. In addition, the single nanoplatform that
simultaneously achieved singlet oxygen and fluorescence enhancement
is rare. In this paper, a novel simultaneously enhanced singlet oxygen
and fluorescence production nanoplatform of AuNR@mSiO2–Ce6–Cy5.5
has been successfully designed and synthesized by surface plasmon
resonance coupling. The as-synthesized nanoplatform achieved a 1.8-fold
enhancement of the singlet oxygen production of Ce6 and a 5.0-fold
enhancement of the fluorescence production of Cy5.5 by surface plasmon
resonance coupling. The as-synthesized nanoplatform simultaneously
enhances the photodynamic therapy and fluorescence imaging of cancer,
which will have great potential in biomedical applications.
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