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This paper describes the formulation and application of a design framework that supports the complex task of multidisciplinary design optimisation of Unmanned Aerial Vehicles (UAVs). The framework includes a Graphical User Interface (GUI), a robust Evolutionary Algorithm optimiser, several design modules, mesh generators and post-processing capabilities in an integrated platform. Traditional deterministic optimisation techniques for MDO are effective when applied to specific problems and within a specified range. A new class of optimisation techniques named Hierarchical Asynchronous Parallel Evolutionary Algorithms (HAPEAs) have shown to be robust as they require no derivatives or gradients of the objective function, have the capability of finding globally optimum solutions amongst many local optima, can be executed asynchronously in parallel and adapted easily to arbitrary solver codes without major modifications. The application of the methodology is illustrated on multi-criteria and multidisciplinary design problems. Results indicate the practicality and robustness of the method in finding optimal solutions and Pareto trade-offs between the disciplinary analyses and producing a set of non dominated individuals.= thickness-to-chord ratio Cm = pitching moment coefficient W SC = wing structural weight AR = wing aspect ratio λ br = taper ratio root to break λ bt = taper ratio break to tip Λ = wing 1/4 chord sweep b l = break location

The purpose of this study was to evaluate elasticity and viscoelasticity in the anterior and deeper stromal regions of the cornea after cross linking with three different protocols using atomic force microscopy (AFM) through indentation. A total of 40 porcine corneas were used in this study and were divided into 4 groups (10 corneas per group): control (no treatment), Dresden (corneal epithelial debridement, riboflavin pretreatment for 30 minutes and a 3mw/cm2 for 30 minutes UVA irradiation), accelerated (corneal epithelial debridement, riboflavin pretreatment for 30 minutes and a 30mw/cm2 for 3 minutes UVA irradiation), and genipin (corneal epithelial debridement and submersion of anterior surface in a 1% genipin solution for 4 hours). Elasticity and viscoelasticity were quantified using AFM through indentation for all corneas, for the anterior stroma and at a depth of 200μm. For the control, Dresden, accelerated, and Genipin groups, respectively, the average Young’s modulus for the anterior stromal region was 0.60±0.58MPa, 1.58 ±1.04MPa, 0.86±0.46MPa, and 1.71±0.51MPa; the average for the 200μm stromal depth was 0.08±0.06MPa, 0.08±0.04MPa, 0.08±0.04MPa, and 0.06±0.01MPa. Corneas crosslinked with the Dresden protocol and genipin were significantly stiffer than controls (p<0.05) in the anterior region only. For the control, Dresden, Accelerated, and Genipin groups, respectively, the average calculated apparent viscosity for the anterior stroma was 88.2±43.7kPa-s, 8.3±7.1kPa-s, 8.1±2.3kPa-s, and 9.5±3.8kPa-s; the average for the 200μm stromal depth was 35.0±3.7kPa-s, 49.6±35.1kPa-s, 42.4±17.6kPa-s, and 41.8±37.6kPa-s. All crosslinking protocols resulted in a decrease in viscosity in the anterior region only (p<0.05). The effects of cross-linking seem to be limited to the anterior corneal stroma and do not extend to the deeper stromal region. Additionally, the Dresden and genipin protocols seem to produce a stiffer anterior corneal stroma when compared to the accelerated protocol.

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