Ethiopia has huge numbers of livestock hampered with high prevalence of infectious disease due to poor disease prevention and control. A five-year retrospective study was conducted to collect data on commonly diagnosed bacterial and viral disease and associated vaccine available at district government veterinary clinic in 2019. The commonly encountered bacterial and viral cattle diseases recorded in the case record book were LSD, CBPP Black leg, Anthrax, Bovine pasteurellosis, and Mastitis. Sheep and goat pox disease, Ovine Pasteurellosis, PPR, CCPP, and anthrax were the common diseases of sheep and goat in the study district. Regarding diseases of poultry, New castle, Infectious Bursal Diseases (Gumboro), Infectious coriza, chicken pox, Coccidiosis, Fowl Typhoid, Fowl Cholera, and Marex are the major once. The commonly available vaccines in the study district were LSD, Black leg, Anthrax, Bovine pasteurellosis, Ovine pasteurellosis, Sheep and Goat Pox, PPR, and vaccine for chicken disease like New castle disease vaccine, Gumboro, Fowl Pox, Fowl typhoid and Fowl cholera were used. Vaccination coverage for Lumpy Skin Disease, Sheep and Goat pox and Newcastle viral diseases were good compared with other diseases. The majority 36% of the population of cattle were vaccinated for LSD in 2019 and the lowest 16% in 2015.The lower portion of shoat 8% and half of the population 50% were vaccinated in 2017 and 2019 respectively. Maximum proportion of Newcastle and Gumboro vaccination coverage were 53% and 42%. The vaccination trends for most of the vaccines were fluctuating from year to year whereas the vaccination trend for LSD was increasing from year to year.
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