Departmental sources Background: The association between C-reactive protein (CRP) and all-cause mortality (ACM) in patients with stable coronary artery disease (CAD) is unclear. Therefore, the aim of the present study was to explore the correlation between CRP and ACM in stable CAD patients. Material/Methods: This study was a secondary analysis. Between October 2014 and October 2017, 196 patients aged 43 to 98 years who had a first diagnosis of stable CAD were recruited into this study. We divided the patients into 4 groups (Quartile 1: 0.01-0.03 mg/dL; Quartile 2: 0.04-0.11 mg/dL; Quartile 3: 0.12-0.33 mg/dL; and Quartile 4: 0.34-9.20 mg/dL) according to the concentration of CRP. The indicator surveyed in this research was ACM. Results: During a median follow-up of 783 days, ACM occurred in 18 patients, with a mortality rate of 9.18% (18/196). Univariate analysis showed that elevated CRP was closely related to ACM in stable CAD patients (P<0.005). After controlling for potential confounding factors by multivariate logistic regression analysis, this relationship still existed. Pearson correlation analysis showed that elevated CRP log10 transform was associated with LVEF (r=-0.1936, P=0.0067). Receiver operating characteristic (ROC) curve analysis showed that the optimal concentration of CRP for the diagnosis of ACM was 0.345, and the area under the curve (AUC) was 0.735. Conclusions: Elevated CRP is associated with ACM in stable CAD patients, and the best diagnostic threshold is 0.345.

At present, the association between uric acid (UA) and brachial-ankle pulse wave velocity (bapWV)has not been well clarified. This study is the second analysis based on a cross-sectional study. 912 participants (average age is 51.5 ± 9.6 years) who underwent medical health examinations were included in this study, UA levels and baPWV were measured. Participants were divided into four groups according to UA levels (Quantile 1: 2.00-4.10 mg/dL; Quantile 2: 4.20-5.20 mg/dL; Quantile 3: 5.30-6.00 mg/dL and Quantile 4: 6.10-9.80 mg/dL), and the differences of baPWV between the four groups were compared. Univariate analysis showed a positive correlation between UA and baPWV [(Quantile 2 vs Quantile 1: 8.85 (−36.05, 53.75); Quantile 3 vs Quantile 1: 60.32 (13.22, 107.42) and Quantile 4 vs Quantile 1: 80.34 (36.19, 124.49)]. After adjusting for confounding factors, the positive correlation between UA and baPWV still exists [(Quantile 2 vs Quantile 1: −9.92 (−60.16, 40.32); Quantile 3 vs Quantile 1: 82.34 (4.00, 160.68) and Quantile 4 vs Quantile 1: 143.13 (0.75, 285.51)]. Furthermore, curve fitting showed that UA and baPWV had a non-linear positive correlation. In conclusion, elevated UA were associated with baPWV, suggesting that UA could be used as a predictor of atherosclerosis.With the continuous development of social economy and the change of people's eating habits, cardiovascular disease has become the main cause of death worldwide 1-4 , especially the number of cardiovascular diseases has been increasing in recent years, this trend will be more pronounced in the future. As is known to all, cardiovascular disease has the clinical characteristics of high incidence, high mortality and high disability rate 5,6 . Once cardiovascular disease occurs, it will bring a huge economic burden to patients and national health security system. Therefore, early identification of cardiovascular risk factors and timely intervention is the focus of clinicians and medical and health institutions.Previous studies have shown that atherosclerosis is an important pathological of cardiovascular disease 7-9 , but early atherosclerosis is lack of specific manifestations, and patients do not have obvious clinical symptoms, thus atherosclerosis is easy to be ignored in its early stages 10 . Therefore, how to identify arterial stiffness early is an important strategy to prevent cardiovascular diseases. With the gradual development of medical equipment and the continuous improvement of people's attention to cardiovascular diseases, the technology of evaluating arterial stiffness by non-invasive method has become the focus of clinicians 11,12 . Brachial-ankle pulse wave velocity (baPWV) 13-16 is the measurement of pulse wave velocity between brachial artery and ankle artery, which mainly reflects the stiffness of the vascular wall of peripheral large and middle arteries 17 . The larger the baPWV value, the higher the degree of arterial stiffness, and then the greater risk of cardiovascular diseases. At present, baPWV has been used as a non-invasi...

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