Three consensus treatment plans were developed for pediatric patients with CNO refractory to NSAIDs and/or with active spinal lesions. Use of these CTPs will provide additional information on efficacy and will generate meaningful data for comparative effectiveness research in CNO.

Significance and Innovations:1. Juvenile systemic sclerosis (jSSc) patients demonstrate significant differences between dcjSSc and lcjSSc subtype regarding frequency of skin, vascular, pulmonary and cardiac involvement.2. Physician global assessment of disease activity and damage is higher in the dcjSSc group.3. jSSc patients with overlap features are not 'protected' from major internal organ involvement and have a higher frequency of lung disease compared to those without overlap features.

ADEs related to antibiotics can be identified by analyzing administrative hospitalization databases. For pneumonia, a common hospitalization diagnosis, there is a defined calculable impact and incidence of antibiotic associated adverse effects. This should be considered in planning hospitalization resource allocation and in developing equitable hospitalization reimbursements. Identifying the nature of antibiotic associated adverse effects may facilitate the development of strategies for reducing these adverse effects.

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