Background:
Migraine is a common neuroinflammatory disorder characterized by recurrent
attacks of pain. Human and experimental models of migraine studies have demonstrated the role
played by COX-2/ iNOS in migraine’s neuroinflammatory pathogenesis. COX-2 and iNOS are closely
linked and both contribute to inflammation and neurogenic pain in the central nervous system. Omega-
3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective
effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression,
as well as their serum levels. The aim of the present study is to evaluate the nutrigenomic effects
of ω-3 fatty acids, nano-curcumin, and a combination of the two, on neuroinflammation and clinical
symptoms in migraine patients.
Methods:
This study reports the results of a clinical trial over a 2-month period, involving 74 episodic
migraine patients who received ω-3 fatty acids, nano-curcumin, a combination of them, or a placebo.
At the start and end of the study, the expression of COX-2/iNOS (in peripheral mononuclear blood
cells isolated from patients) and COX-2/iNOS serum levels were measured, using real-time PCR and
ELISA respectively. The frequency, severity and duration of pain attacks were also recorded.
Results:
The results of the present trial showed that ω-3 fatty acids and nano-curcumin can reinforce
each other’s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.
In addition, the combination of ω-3 and nano-curcumin significantly reduced the frequency, severity
and duration of headaches (P<0.05).
Conclusion:
These findings indicate that combination therapy of ω-3 fatty acids and nano-curcumin
can be considered as a promising new approach in migraine prevention.
Objective
The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.
Results
In this study, 80 patients were randomly divided in to 4 groups to receive for 2 months. Both serum levels and gene expression of VCAM showed remarkable decreases after single W-3 and after combined W-3 and nanocurcumin interventions. However, a borderline significant change and no remarkable change were observed after single nanocurcumin supplementation and in control group, respectively. While a significant difference between study groups in VCAM concentrations existed, there was no meaningful difference in VCAM gene expression among groups. It appears that the W-3 and combined W-3 and nanocurcumin can relieve VCAM serum level and its gene expression in patients with episodic migraine. Moreover, the combination of W-3 with nanocurcumin might cause more significant declines in VCAM level in the serum of migraine patients than when W-3 is administered alone.
Trial Registration: This study was registered in Iranian Registry of Clinical Trials (IRCT) with ID number: NCT02532023.
IntroductionOne of the rare manifestations of systemic neoplasia is intramedullary spinal cord metastasis that causes serious diagnostic and therapeutic dilemma. It has been very rarely reported as the initial manifestation of carcinoma. This is report of a metastatic renal cell carcinoma initially presented with intramedullary spinal cord lesion, to our knowledge there are few similar reports in literature.Case presentationWe report a 51-year-old Iranian woman who presented with back pain and paraparesis. MR imaging study of her spine showed an enhancing cystic lesion at the level of conus medullaris. Despite detailed investigation, no specific aetiology was found till a bone scan obtained to evaluate an agonizing pain on the dorsum of the left hand revealed photon deficient area within the left kidney in addition to oseoblastic bony lesions. After thorough imaging investigation she underwent radical nephrectomy which confirmed renal cell carcinoma.ConclusionConsidering the prevalence of cancer, it is imperative that clinicians be mindful of occult carcinoma as the cause of suspicious intramedullary spinal cord lesion.
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