Background: Endometriosis is an estrogen-dependent gynecological inflammatory condition that may lead to infertility and recurrent pelvic pain. The purpose of this research was to determine the efficacy and safety of Salvia miltiorrhiza-containing Chinese herbal medicine (CHM) combined with gonadotropin-releasing hormone agonist (GnRH-a) for postoperative endometriosis management.Methods:Eight databases were systematically searched before October 2021, including PubMed, Embase, Cochrane Library, Scopus, Web of Sceince, CNKI, VIP, and Wanfang. Finally, all randomized controlled studies comparing Salvia miltiorrhiza-containing CHM paired with GnRH-a to GnRH-a alone for postoperative endometriosis management were included.Results: A total of 10 trials involving 836 patients were reported and analyzed. Compared with the control group, the Salvia miltiorrhiza-containing CHM combined with GnRH-a group showed significant superiority in decreasing endometriosis recurrence (risk ratio [RR] = 0.26; 95% confidence intervals [CI]: 0.16–0.41) and increasing the pregnancy rate ([RR] = 1.96; 95% CI: 1.58–2.44). Similarly, the effect of the Salvia miltiorrhiza-containing CHM combined with GnRH-a on CA-125 serum levels was positive (standardized mean difference [SMD] = -0.79; 95% CI: −1.11 to −0.47). Furthermore, this group showed a significant reduction in adverse effects.Conclusion: The results indicate that Salvia miltiorrhiza-containing CHM may be a viable choice for postoperative endometriosis therapy, with the potential to enhance pregnancy while decreasing recurrence and adverse effects.
This paper proposes to improve the output performance of a piezoelectric pump by matching the resonant frequency of the resonator to the optimal operating mode of bridge-type polydimethylsiloxane (PDMS) check valves. Simulation analyses reveal that the side-curling mode of the PDMS valve is conducive to liquid flow and exhibits a faster frequency response compared with the first bending mode. The first bending resonant frequency of a beam-type piezoelectric resonator was tuned close to the side-curling mode of the PDMS valve by adjusting the weight of two mass blocks installed on both ends of the resonator, so that both the resonator and the valve could work at their best conditions. Experiments were conducted on a detachable prototype piezoelectric pump using PDMS valves with three different lengths. The results confirm that the peak flowrate at the resonant point of the pump reaches its maximum when the resonant frequencies between the resonator and the valve are matched. Maximum peak flowrates of 88 mL/min, 72 mL/min and 70 mL/min were achieved at 722 Hz, 761 Hz and 789 Hz, respectively, for diaphragm pumps using five-, four- and three-inlet-hole PDMS valves, under a driving voltage of 300 Vpp.
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