It was concluded that LBW led to lower body measurements, whereas rapid postnatal weight gain determined higher BMI and WC among school age children.

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The objective of this study was to determine the prevalence of anemia and vitamin A deficiency and to analyze the association of food insecurity with hemoglobin levels and serum retinol in children under 5 years of age. This was a cross-sectional study with 501 families from Gameleira and 458 families from São João do Tigre. Food insecurity was assessed according to the Brazilian Food Insecurity Scale. Hemoglobin and serum retinol levels were classified according to the WHO. Socioeconomic and environmental conditions and biological indicators of children were analyzed as hemoglobin and serum retinol determinants. The prevalence of anemia and vitamin A was higher in Gameleira compared to São João do Tigre. Moderate and severe food insecurity of families was 75% in Gameleira and 64% in São João do Tigre. Maternal education, per capita family income, not having a color TV, untreated water supply, type of flooring (dirt), and child age (< 2 years) in Gameleira were associated with hemoglobin levels in the linear regression analysis. In São João do Tigre the association with hemoglobin levels was only for (no) motorcycle and child age. Variables per capita family income and sex in Gameleira and no mobile phone and lack of sanitation in São João do Tigre were statistically associated with serum retinol levels. The nutritional status of these populations is similar in terms of food insecurity but may present great differences in terms of the prevalence of specific nutritional deficits and their determinants.

Background The implications of congenital Zika Virus (ZIKV) infections for pediatric neurodevelopment and behavior remain inadequately studied. The aim of this study is to investigate patterns of neurodevelopment and behavior in groups of children with differening severities of ZIKV-related microcephaly and children with prenatal ZIKV exposure in the absence of microcephaly. Methods We conducted a cross-sectional study, nested in a cohort, of 274 children (aged 10–45 months) who were born during the peak and decline of the microcephaly epidemic in Northeast Brazil. Participants were evaluated between February 2017 and August 2019 at two tertiary care hospitals in Recife, Pernambuco, Brazil. We analyzed the children in four groups assigned based on clinical and laboratory criteria: Group 1 had severe microcephaly; Group 2 had moderate microcephaly; Group 3 had prenatal ZIKVexposure confirmed by maternal RT-PCR testing but no microcephaly; and Group 4 was a neurotypical control group. Groups were evaluated clinically for neurological abnormalities and compared using the Survey of Wellbeing of Young Children (SWYC), a neurodevelopment and behavior screening instrument validated for use in Brazil. Children with severe delays underwent further evaluation with an adapted version of the SWYC. Results Based on the SWYC screening, we observed differences between the groups for developmental milestones but not behavior. Among the 114 children with severe microcephaly of whom 98.2% presented with neurological abnormalities, 99.1% were ‘at risk of development delay’ according to the SWYC instrument. Among the 20 children with moderate microcephaly of whom 60% presented with neurological abnormalities, 65% were ‘at risk of development delay’. For children without microcephaly, the percentages found to be ‘at risk of developmental delay’ were markedly lower and did not differ by prenatal ZIKV exposure status: Group 3 (N = 94), 13.8%; Group 4 (N = 46), 21.7%. Conclusions Among children with prenatal ZIKV exposure, we found a gradient of risk of development delay according to head circumference. Children with severe microcephaly were at highest risk for delays, while normocephalic ZIKV-exposed children had similar risks to unexposed control children. We propose that ZIKV-exposed children should undergo first-line screening for neurodevelopment and behavior using the SWYC instrument. Early assessment and follow-up will enable at-risk children to be referred to a more comprehensive developmental evaluation and to multidisciplinary care management.

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