It is often necessary to adjust a patient (92,8 -1-35,0 rain, P < 0,05). Aprks la physioth~rapie, le dosage de midazolam n~cessite 1,8 -t-0.5 ajustements comparativement ~ 0,4 + O,2 pour le propofol (P < 0,05). Pendant la physioth~rapie, la posologie du propofol doit ~tre ajustde 3,5 fois comparativement ~ 3,5 pour celle du midazolam (NS) Most patients admitted to intensive care units, who are subsequently ventilated artificially, require some form of sedation during at least part of their stay and it is common practice to use either midazolam or propofol by continuous intravenous infusion. It has been shown t-6 that over a 24-hr period both midazolam and propofol offer good quality of sedation and that the quicker wake up time that is seen with propofol may mean that this agent has benefits over midazolam. These studies, however, CANJ ANAESTH 1993 / 40:12 / pp 1142