This paper analyzes the relationship between freight accessibility and logistics employment in the US. It develops an accessibility measure relevant for logistics companies based on a gravity model. This allows to analyze accessibility of US counties focusing on four different modes of transportation: road, rail, air, and maritime. Using a Partial Least Squares model, these four different freight accessibility measures are combined into two constructs, continental and intercontinental freight accessibility, and related to logistics employment, differentiating counties inside metropolitan areas from those outside. Results show that highly accessible non-metropolitan counties attract more logistics employment than other non-metropolitan counties. In metropolitan counties, no significant relationship was found between freight accessibility and logistics employment. This is primarily explained by the highly significant relations of both freight accessibility and logistics employment with county population.