With a view to finding a relationship betwccn immurle responsc and MHC in man. 8. 3 D negativc mothers with allo-into-I> antibodies and 26 PL"' negative mothers with allo-anti-PL"' antibodies were invcstigated as regards their HLA-A, B and DR antigens. We have found that therc is a highly significant relation between thc DR? antigen and an immune response to the PL"' antigen, but none to the D antigen.
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