This study analyses the ultrastructure of the plasma cell population of periodontitis-affected soft tissue close to the advancing front of interdental lesions. Biopsies from 20 patients and 3 control volunteers were examined: 5 with treated adult periodontitis (AP), 5 with untreated AP, 5 with treated juvenile or post-juvenile periodontitis (JP) and 5 with untreated JP. Plasma cell (PC) counts increased significantly (p less than 0.05) with lesion severity. They were absent from epithelium and sparse in the clinically healthy control specimens. Degenerate PC tended to be more numerous within JP tissue but differences were not significant (p greater than 0.05) when compared to AP. Intact plasma cells were never seen within JP superficial connective tissue. Russell bodies were small and few in number. The presence of degenerated plasma cells indicated normal formation and release of immunoglobulins within the tissues of AP and JP. Increased counts of degenerate PC and tissue destruction in JP suggested a correlation, possibly attributable to anti-collagen antibody secretion.

Background: Long-term success of dental implants has been demonstrated when placed simultaneously with or after a socket grafting procedure. Although optimal bone formation can be from 6 to 9 months or longer with grafting materials other than autogenous bone, there is the avoidance of potentially hazardous harvesting autogenous bone.Methods: This study evaluated bone formation following grafting of 22 postextraction alveolar sockets with a bioactive calcium phosphosilicate putty (CPS putty) graft material.Results: At 5 to 6 months postgrafting, there was bone regeneration showing both normal clinical attributes and radiographic trabecular appearance. Histomorphometric analysis revealed average vital bone content of 48.2 ± 6.8% to residual graft content of 2.4 ± 1.4% for the 22 sockets in the study, at an average healing period of 5.4 ± 1.5 months. Conclusions:The high percentage of vital bone content after a relatively short healing phase, suggests that CPS putty can be a reliable choice for osseous regeneration in cases of crest preservation and implant related surgeries.

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The purpose of this study was to investigate the interaction between dental plaque and the oxidative metabolism of blood (PB), crevicular (CR) and salivary (SAL) PMN. Data indicated that supragingival plaque induced an in vitro production of chemiluminescence by both PB and CR--PMN in a dose-dependent manner with a maximum activity after 30 min incubation. Comparison between PB, CR and SAL-PMNs indicated that 1) both CR and SAL-PMNs spontaneously produced large quantities of oxygen radicals, 2) CR and SAL-PMNs further produced oxygen radicals upon phorbol myristate acetate or opsonized-zymosan stimulation, and 3) SAL-PMN could not be further activated by supragingival plaque.