BRCA1 and BRCA2 mutations predispose to select cancers 1-3 , and disease-specific screening and preventative strategies have reduced cancer mortality in affected patients 4,5. These classical tumors suppressor genes have tumorigenic effects associated with somatic biallelic inactivation, though haploinsufficiency may also promote tumor formation and progression 6,7. Moreover, BRCA1/2-Reprints and permissions information is available at www.nature.com/reprints.
Debra Goldman owns stock in Johnson and Johnson Jaclyn F. Hechtman has received honoraria from Cor2Ed, WebMD, and Axiom Healthcare Strategies as well as research funding from Bayer, Loxo Oncology, and Boehringer Ingelheim.
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