No abstract

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. The introduction of a novel class of drugs, the Hedgehog pathway inhibitors, into clinical practice has ushered in a new treatment algorithm for the treatment of difficult BCC cases. In this review we present the latest available evidence and discuss areas for further research in this rapidly evolving field.

This study proposes a novel approach in melasma scoring using digital image analysis. It holds promise as a tool that would enable clinicians worldwide to standardize melasma severity scoring and outcome measures in an easy and reproducible manner, enabling different treatment options to be compared accurately.

Blood cultures should be performed for patients with cellulitis who have factors increasing the risk of bacteraemia, such as presence of lymphoedema, ipsilateral orthopaedic device implantation, leucocytosis of > 13.5 × 10(6) μL, liver cirrhosis or chronic kidney disease, and other forms of immunosuppression. Bacteraemia in cases of cellulitis of the leg is a prognostic factor for increased length of hospitalization stay and recurrence of cellulitis.

IL36RN) is associated with generalized pustular psoriasis. The defect appears to increase expression of IL-8, a neutrophil recruiter and a target of cyclosporine. 2,6 Whether the IL36RN gene played a role in our cases is uncertain.Poststreptococcal pustulosis is a rare neutrophilic disorder that occurs as a complication following streptococcal infections. We describe 2 cases in a mother and daughter that responded quickly to a 6-day regimen of low-dose cyclosporine. The rapid response suggests that short courses of cyclosporine may be used as an alternative to systemic corticosteroids in patients with PSP.