at We thank M. Kundi for helpful discussions and suggestions for improvements. This project was funded by the Austrian Federal Ministry of Science and Transport (GZ 70.017/2-Pr/4/87). Partial support was also provided by the "Jubiläumsfond der Österreichischen Nationalbank" under grant 6930. The Austrian Federal Ministry of Science and Transport provides general financial support for the
We compared 121 replicate rodent carcinogenicity assays from the two parts (National Cancer Institute/National Toxicology Program and literature) of the Carcinogenic Potency Database (CPDB) to estimate the reliability of these experiments. We estimated a concordance of 57% between the overall rodent carcinogenicity classifications from both sources. This value did not improve substantially when additional biologic information (species, sex, strain, target organs) was considered. These results indicate that rodent carcinogenicity assays are much less reproducible than previously expected, an effect that should be considered in the development of structure-activity relationship models and the risk assessment process.
The primary aim of the present investigation was to study
possible adverse effects of groundwater from an aquifer
south of Austria's capital, Vienna, and to relate these
toxicological effects to routinely measured
physical/chemical
parameters. Fourty-three water samples were tested
for
genotoxic and ecotoxic effects. For genotoxicity
testing
the Salmonella/microsome assay, the micronucleus
test
with primary rat hepatocytes and micronucleus tests with
plants (Tradescantia, Vicia faba) were
used. In ecotoxicity
tests, algae (Selenastrum capricornutum), water cress
(Lepidium sativum), and water flea (Dapnia
magna) were
studied as target organisms. In genotoxicity assays,
10
samples (23%) gave a weak positive response with a single
end point, but only one sample (2%) was genotoxic in
three different test systems. Thirty-six samples (86%)
caused
adverse effects in ecotoxicity assays. Plants (algae
and
water cress) were more sensitive than daphnie. No
correlations between toxic effects and physical/chemical
parameters were detected. The genotoxicity
experiments
indicate presently a low risk from genotoxic compounds.
The
ecotoxic (especially phytotoxic) properties of many water
samples raise concern about their suitability for
irrigation
purposes. The lacking correlation between results
from
toxicity tests and physical/chemical data indicates that it
is
presently impossible to predict toxic properties from
routine
physical/chemical measurements with a sufficient level of
safety. It is therefore important to include
biological
toxicity assays in groundwater monitoring programs.
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