In high-risk patients with end-stage renal disease, the prevalence of CAD and the incidence of MACE were high. Significant CAD or cardiovascular complications were not related to the majority of classic risk factors. Patients with diabetes, PAD, or previous MI are at higher risk of CAD, MACE, or both and, thus, must be referred for invasive diagnostic procedures.
We concluded that in high-risk RTC, diabetes confers a cardiovascular risk comparable to that of CAD in patients without diabetes, independent of coronary obstruction. In patients with diabetes, concomitant CAD does not add to the already very high cardiovascular risk of this population.
SummaryObjective: To assess the importance of the interaction between leukocyte integrin Mac-1 ( M 2 ) and platelet glycoprotein (GP) Ib-for leukocyte recruitment after vascular injury and the effect of the neutralization of the Mac-1-GPIb interaction on cell proliferation and the neointimal hyperplasia triggered by the vascular injury.Methods: A peptide called M2 or anti-M2 antibody was developed to block the Mac-1-GPIb interaction. This peptide was injected and compared to a control-peptide in C57B1/6J mice submitted to vascular injury of the femoral artery with a guide wire. One, five or 28 days after the vascular injury, the femoral arteries were removed for morphometric and immunohistochemical analyses.
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