Problem statement: In Selva de Chiapas, Mexico, the traditional farming technique of slash-fell-burn used on hillside fields has caused severe soil deterioration. Consequently, indigenous farmers reacted by developing several agroecological practices that improve the physical, chemical and biological fertility of the soils. Standing out among these techniques is the use of Mucuna (Mucuna deeringianum Bort.) in rotation with maize (Zea mays L). Approach: The objective of this study was to determine the effect of the maize-mucuna system on soil fertility, ecosystem diversity and maize crop yield. The study was conducted in the Tulija Valley, Chiapas, in the autumn-winter growing season (November-April). A completely random design was applied to four periods of consecutive maize-mucuna cropping (0, 5, 10 and 15 years) in order to analyze the most significant variables related to soils, weeds, seed bank and yield. Results: The results obtained reveal the higher nutrient concentration in the topsoil (0-15 cm) and better crop yield in the treatments with Mucuna rotation. No direct relationship was observed between nutrient content and duration of maize-mucuna system usage. However, the diversity of weeds and similarity of species both diminished where this farming method was used. Conclusion/Recommendations: It was determined that the use of the maize-mucuna agroecosystem helps to increase and maintain agroecological sustainability, supporting this practice that has been adapted and utilized by indigenous Choles for more than 30 years.
Background: Development of simple, rapid, and sensitive assay for the determination of loratadine in order to investigate its pharmacokinetic parameters in human plasma and its application in bioequivalence study of Loratadine 10mg Oral Disintegrated Tablets manufactured locally (test) and originally (Reference). Methods: After extraction of loratadine from human plasma, it was chromatographed with mobile phase consisting of 0.5% formic acid: Acetonitrile (10:90 V/V) at flow rate 0.6ml/min, ESI positive mode, and m/z 383→337 for Loratadine. The bioequivalence study was conducted in a Two-Way Open-Label, Crossover design involving 24 volunteers. The criteria used to assess bioequivalence of the two products were AUC 0-t , AUC 0-inf , C max , and T max . Results: the described method of analysis showed that the average recovery of Loratadine from human plasma was 102.685%. The limit of Quantitation was 0.05ng/ml, and the correlation coefficient (r 2 ) was equal to 0.999893. Statistical analysis (ANOVA) of the measured parameters showed that there was no significant difference between the two products. Conclusion:The LC/MS/MS method presented is direct, simple, reproducible, sensitive, and linear for the determination of Loratadine in human plasma, and is adequate for clinical pharmacokinetic studies, besides the test product was found to be bioequivalent to the reference and both products can be considered interchangeable in medical practice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.