Behçet syndrome(BS), also known as Behçet disease (BD), is characterized by recurrent oral aphthae and any of several systemic manifestations including genital aphthae, ocular disease, skin lesions, gastrointestinal involvement, neurologic disease, vascular disease or arthritis. Sarcoidosis is a multisystem granulomatous disorder of unknown etiology that affects individuals worldwide and is characterized pathologically by the presence of noncaseating granulomas in involved organs. BD may be confused with sarcoidosis because they are both multisystem inflammatory disorders presenting with uveitis, polyarthritis, meningitis, cardiovascular disease, erythema nodosum, and other cutaneous lesions, and abnormal chest radiographs.
Introduction Castleman’s Disease (CD) is a rare, systemic disease with histopathological features of angiofollicular lymph node hyperplasia. In the literature, there are case-level reports that mimic or coexist with Systemic Lupus Erythematosus (SLE) clinically and laboratoryly. Is this condition two separate diseases or is it an imitation of each other? Case Presentation A 73-year-old female patient was admitted to our clinic with arthritis, lymphadenopathy (LAP), fever, weight loss and malar rash. He had a history of idiopathic thrombocytopenic purpura (ITP) and thrombosis in the right leg tibialis posterior and dorsalis pedis arteries. Excisional LAP biopsy indicated a diagnosis of hyaline vascular type CD. She had antinuclear antibody >1/80 homogeneous pattern, anti-dsDNA, anti-Sm positivity, hypocomplementemia (C3 and C4), pleural and pericardial effusion. For this reason, the classification criteria of the European League Against Rheumatism/American College of Rheumatology (2019 EULAR/ACR) were studied. Clinical findings, ITP history, antibody positivity, malar rash and arthritis led us to the diagnosis of SLE. She was treated with 1 mg/kg day prednisolone and hydroxychloroquine 200 mg 2x1. Azathioprine 2.5 mg/kg daily was added to the patient whose complaints did not improve. In the follow-ups, she completely recovered clinically and laboratory. Conclusions SLE and CD are systemic diseases that overlap in many ways. The literature review shows that these two diseases may mimic each other or may coexist. This situation may be a reflection of a pathophysiological process that has not yet been clarified. This confusing process also affects the treatment decision. This confusing process also affects the treatment decision.
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