Photosensitivity reactions have been reported with almost all ARBs in VigiBase(®) with a positive disproportionality for irbesartan and losartan. Considering that ARBs share the same chemical structure, which may have the same response to sunlight, it is plausible to consider photosensitivity as a possible class effect. Physicians and patients should be aware of potentially serious photosensitivity reactions related to treatment with ARBs.
The off-label use of ketorolac is widespread in Italy. This use increases the risk of serious ADR, especially in in case of prolonged duration of treatment and in elderly patients. The Italian Medicine Agency has decided to accurately monitor the appropriate use of the drug in Italy and, if necessary, take measures in order to minimize the risks.
In this study, we highlight a possible association between gynecomastia and tamsulosin use. To our knowledge, this association has not been described before and could represent a potential signal.
The PMN,thanks to its ability to engulf and kill microorganisms, works as first defence against invading bacteria.whether or nQt antibiotics are administered.Because ofthe so-called "postantibiotic effectl',antibiotics in vitro slow down bacterial growth and metabolism for a period stretching beyond the exposure.0ur study aims at assaying the capacity of E to influence PMN activity against microorganisms. PMN function was evaluated by chemotaxis,using the modified Boyden technique,and by Candida Albicans phagocytosis and killing using Lehre, and Cline technique.PMN8s were isolated from the peripheral blood of 9 healthy children(mean age 7,1622.82) treated with a single oral dose of 25mg/Kg of E. Blood wase drawn prior to the administration of the antibiotic(reference value of PMN activity),2 hrs. later (when E blood levels reach their peakland 8 hrs. later(2 hrs. after disappearance of E from the blood).The results show that,from the 8th hour on.there is a considerable increase in PMN phagocytic and killer activity(phF 0,171 c0.04 before;0,40+0,08 after 8 hrs.;p<<0,001-% killing 23,08+4,16 before;32,6+5,1 after 8 hrs.;p
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