MicroRNAs (miRNAs) are short, non-coding and endogenous RNAs that played as important roles in the proliferation and metastasis of tumors. In this study, we determined the role of miR-18a in the regulation of HCC cell motility. We showed that miR-18a expression was upregulated in human HCC tissues and cell lines. Moreover, Elevated expression of miR-18a promoted the HCC cell proliferation and migration. KLF4 was identified as a direct target of miR-18a in HCC cells. Furthermore, overexpression of KLF4 attenuated the effects of miR-18a on the regulation of HCC cell motility. The expression of KLF4 was negatively associated with the expression of miR-18a expression in HCC tissues. We also showed that the cell cycle inhibitor p21 was aberrantly downregulated in HCC cells, whereas this inhibition was reversed by miR-18a inhibitor. These data indicated that miR-18a may play a positive role in hepatocellular carcinoma by promoting the proliferation and migration of HCC cells through targeting KLF4 as well as downstream p21.
A hypernucleus, a sub-atomic bound system with at least one hyperon, is a great test ground to investigate nuclear forces and general baryonic interactions with up, down and strange quarks. Hypernuclei have been extensively studied for almost seven decades in reactions involving cosmic-rays and with accelerator beams. In recent years, experimental studies of hypernuclei have entered a new stage using energetic collisions of heavy-ion beams. However, these investigations have revealed two puzzling results related to the lightest three-body hypernuclear system, the so-called hypertriton and the unexpected existence of a bound state of two neutrons with a Λ hyperon. Solving these puzzles will not only impact our understanding of the fundamental baryonic interactions with strange quarks, but also of the nature of the deep interior of neutron stars. In this Perspective, we discuss approaches to solving these puzzles including experiments with heavy-ion beams and the analysis of nuclear emulsions using state-of-the-art technologies. We summarise on-going projects and experiments at various facilities worldwide and outline future perspectives.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.