reast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare lymphoma associated with long-term placement of textured breast implants. [1][2][3][4] The first case of BIA-ALCL was reported in 1997 5 and, until recently, this disease process was poorly described. There have been approximately 600 to 700 documented cases worldwide, and because of the rarity of the disease, the National Comprehensive Cancer Network did not release staging guidelines until 2017 6 (most recently updated in 2019). BIA-ALCL has been the subject of avid research in plastic surgery, oncology, immunology, and cellular biology, in addition to governmental regulation; internationally, 38 countries have banned or restricted sale of Allergan Biocell (Allergan, Inc., Dublin, Ireland) textured expanders because of concern of BIA-ALCL.
Doppler signal in the site of most intense pain can predictably document the presence of an artery in the most painful site and lead to precise location of the nerve irritation by a vessel and successful removal of the offending artery.
The described approach is a promising starting point for drug screening in osteosarcoma because it is tailored to evaluate micrometastatic disease. A reliable and rapid method to identify novel therapeutics is critical to improve stagnant outcomes for patients with osteosarcoma.
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