Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov ( NCT04381936 ). Findings Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research.

We combine optical, near-infrared and mid-infrared spectra and photometry to construct expanded spectral energy distributions (SEDs) for 145 field age (>500 Myr) and 53 young (lower age estimate <500 Myr) ultracool dwarfs (M6-T9). This range of spectral types includes very low mass stars, brown dwarfs, and planetary mass objects, providing fundamental parameters across both the hydrogen and deuterium burning minimum masses for the largest sample assembled to date. A subsample of 29 objects have well constrained ages as probable members of a nearby young moving group (NYMG). We use 182 parallaxes and 16 kinematic distances to determine precise bolometric luminosities (L bol ) and radius estimates from evolutionary models give semi-empirical effective temperatures (T eff ) for the full range of young and field age late-M, L and T dwarfs. We construct age-sensitive relationships of luminosity, temperature and absolute magnitude as functions of spectral type and absolute magnitude to disentangle the effects of degenerate physical parameters such as T eff , surface gravity, and clouds on spectral morphology. We report bolometric corrections in J for both field age and young objects and find differences of up to a magnitude for late-L dwarfs. Our correction in Ks shows a larger dispersion but not necessarily a different relationship for young and field age sequences. We also characterize the NIR-MIR reddening of low gravity L dwarfs and identify a systematically cooler T eff of up to 300K from field age objects of the same spectral type and 400K cooler from field age objects of the same M H magnitude.

We have conducted a 4030-square-deg near-infrared proper motion survey using multi-epoch data from the Two Micron All-Sky Survey (2MASS). We find 2778 proper motion candidates, 647 of which are not listed in SIMBAD. After comparison to DSS images, we find that 107 of our proper motion candidates lack counterparts at B-, R-, and I-bands and are thus 2MASS-only detections. We

We present a kinematic analysis of 152 low surface gravity M7-L8 dwarfs by adding 18 new parallaxes (including 10 for comparative field objects), 38 new radial velocities, and 19 new proper motions. We also add low- or moderate-resolution near-infrared spectra for 43 sources confirming their low surface gravity features. Among the full sample, we find 39 objects to be high-likelihood or new bona fide members of nearby moving groups, 92 objects to be ambiguous members and 21 objects that are non-members. Using this age-calibrated sample, we investigate trends in gravity classification, photometric color, absolute magnitude, color–magnitude, luminosity, and effective temperature. We find that gravity classification and photometric color clearly separate 5–130 Myr sources from >3 Gyr field objects, but they do not correlate one to one with the narrower 5–130 Myr age range. Sources with the same spectral subtype in the same group have systematically redder colors, but they are distributed between 1 and 4σ from the field sequences and the most extreme outlier switches between intermediate- and low-gravity sources either confirmed in a group or not. The absolute magnitudes of low-gravity sources from the J band through W3 show a flux redistribution when compared to equivalently typed field brown dwarfs that is correlated with spectral subtype. Low-gravity, late-type L dwarfs are fainter at J than the field sequence but brighter by W3. Low-gravity M dwarfs are >1 mag brighter than field dwarfs in all bands from J through W3. Clouds, which are a far more dominant opacity source for L dwarfs, are the likely cause. On color–magnitude diagrams, the latest-type, low-gravity L dwarfs drive the elbow of the L/T transition up to 1 mag redder and 1 mag fainter than field dwarfs at M J but are consistent with or brighter than the elbow at M W1 and M W2. We conclude that low-gravity dwarfs carry an extreme version of the cloud conditions of field objects to lower temperatures, which logically extends into the lowest-mass, directly imaged exoplanets. Furthermore, there is an indication on color-magnitude diagrams (CMDs; such as M J versus (J–W2)) of increasingly redder sequences separated by gravity classification, although it is not consistent across all CMD combinations. Examining bolometric luminosities for planets and low-gravity objects, we confirm that (in general) young M dwarfs are overluminous while young L dwarfs are normal compared to the field. Using model extracted radii, this translates into normal to slightly warmer M dwarf temperatures compared to the field sequence and lower temperatures for L dwarfs with no obvious correlation with the assigned moving group.