Objectives The objective of the study is to determine the efficacy of Emergency Severity Index (ESI) tool in early recognition of “sepsis” and “septic shock” at the triage of an emergency room at a tertiary care hospital in Pakistan.Results A total of 240 patients were included in this study. The area under the curve (AUC) for the ESI score I for septic shock was 0.943 [0.921–0.964] with the optimal cutoff value of 2.0 with sensitivity of 88.5% and specificity of 100%. Similarly, the sensitivity and specificity of ESI score II for the diagnosis of sepsis was found to be 100.00% (CI 97.63–100.00%) and 66.28% (CI 55.28% to76.12%) with accuracy of 87.92% (83.11–91.76%)
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