Docetaxel followed by hormone therapy of limited duration may provide disease control in subgroups of men experiencing failure after local treatments for PC.

Bilateral adrenocortical hyperplasia was present in 24 of 27 dogs with hyperadrenocorticalism. Two dogs had a unilateral adenoma, and one had a carcinoma of the adrenal cortex. Bilateral cortical hyperplasia was diffuse or nodular. The difference between the two patterns of hyperplasia was not associated with any consistent varation in the clinical or endocrinologic features. In the three dogs with adrenal cortical neoplasia there was marked cortical atrophy of the contralateral adrenal gland. Extracapsular nodular hyperplasia was common in the adrenals of dogs with hyperadrenocorticalism and also in older control dogs without endocrine disease. Ten of the dogs with bilateral adrenocortical hyperplasia were examined postmortem; two had a chromophobe adenoma of the pituitary, but no pituitary lesion was found in the others.

The effect of interferon-beta1b (IFN-beta) on human cerebral blood flow distribution was examined in five multiple sclerosis patients using functional brain single-photon emission tomography (SPECT). Of nine regions of interest studied, only the basal ganglia exhibited a significant change (increase) in relative photon emission intensity (i.e., relative blood flow) when comparing SPECT scans obtained 6 h after s.c. IFN-beta injection with scans obtained at the same time of day (noon) 30 h after IFN-beta injection (IFN-beta-free day). The increase in relative blood flow to the basal ganglia following IFN-beta injection correlated positively with changes in mean arterial pressure (MAP). Additional studies will be required to determine the relevance of these observations for IFN-beta-induced central nervous system side effects.

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