The Myocardial Performance Index (MPI), also known as the Tei Index, is a measure of the overall performance of the heart that takes into account both systolic and diastolic function. It is a non‐invasive echocardiographic index that provides information about the efficiency of the heart's pumping action. The MPI is a useful tool for evaluating cardiac function in various clinical conditions, such as heart failure, myocardial infarction, and cardiomyopathy. A higher MPI value indicates poorer cardiac function, while a lower MPI value indicates better cardiac function. This review will give a summary of the relevant MPI literature, provide a methodology and technical aspects, and make research recommendations.
Purpose: Inappropriate dosing of direct oral anticoagulants is associated with an increased risk of stroke, systemic embolism, major bleeding, cardiovascular hospitalization, and death in patients with atrial brillation. The main goal of the study was to determine the prevalence and associated factors of inappropriate dosing of direct oral anticoagulants in real-life settings.Methods: This study was a multicenter, cross-sectional, observational study that included 2,004 patients with atrial brillation. The study population was recruited from 41 cardiology outpatient clinics between January and May 2021. The main criteria for inappropriate direct oral anticoagulant dosing were de ned according to the recommendations of the European Heart Rhythm Association.Results: The median age of the study population was 72 years and 58% were women. Nine hundred and eighty-seven patients were prescribed rivaroxaban, 658 apixaban, 239 edoxaban, and 120 dabigatran. A total of 498 patients (24.9%) did not receive the appropriate dose of direct oral anticoagulants. In a logistic regression model, advanced age, presence of chronic kidney disease, presence of permanent atrial brillation, prescription of reduced doses of direct oral anticoagulants, prescription of edoxaban treatment, concomitant use of amiodarone treatment, and non-use of statin treatment were signi cantly associated with potentially inappropriate dosing of direct oral anticoagulants.
Conclusion:The study demonstrated that the prevalence of inappropriate direct oral anticoagulant dosing according to the European Heart Rhythm Association recommendations was 24.9% in patients with atrial brillation. Several demographic and clinical factors were associated with the inappropriate prescription of direct oral anticoagulants.
In the following article published in Cardiovascular Drugs and Therapy, December 17, 2022, the subtitle of Table 1 included an incorrect phrase: "For patients receiving rivaroxaban or for patients receiving apixaban or for patients receiving edoxaban." This has been deleted and replaced with the correction subheading "For patients receiving dabigatran.
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