Infectious diseases caused by microorganisms are the main cause of high morbidity and mortality in the world. One of the plants that have the potential as an antiseptic is a lahuna leaf. Lahuna leaves contain active antibacterial compounds and the addition of betel leaf to the liquid soap formulations can strengthen the activity of the antiseptic produced. The purpose of this research is to test the effectiveness of liquid soap formulations of lahuna leaves and betel leaves as an antiseptic. The methods used include phytochemical screening, physical observation of liquid soap formulations, and antibacterial activity tests using agar diffusion methods. The results of the phytochemical analysis showed that lahuna leaves contain flavonoids, tannins, terpenoids, and alkaloids, while betel leaves contain flavonoids, saponins, tannins, terpenoids, and alkaloids. The liquid soap formulation of lahuna leaves and betel leaves has a clear yellow color, distinctive aroma, liquid form, rough taste, and lots of foam and has very strong inhibition against Staphylococcus aureus which is characterized by clear zones formed for each formulation I (22.4 mm), formulation II (21.8 mm) and formulation III (20.1 mm). These results indicate the potential of liquid soap formulations of lahuna leaves and betel leaves as antiseptic soap.
Lahuna and betel are plants that have been used traditionally as medicine. The content of secondary metabolites in lahuna and betel leaves can be used as active compounds in the manufacture of liquid soap. This study aims to evaluate liquid soap formulations of lahuna leaf extract and betel leaf extract and to test its activity against Escherichia coli. The research method used was pH test, organoleptic test, homogeneity test, foam height test, water content test according to SNI 1996 and antibacterial activity test with agar diffusion method. The results showed that the liquid soap formulation was in accordance with SNI 1996 which was based on pH test, organoleptic test, homogeneity test, foam height test and water content test. Also, the liquid soap formulation has very strong activity against Escherichia coli characterized by a clear zone that is formed more than 19 mm
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