Syok septik adalah bagian dari sepsis yang ditandai adanya perubahan sirkulatorik, seluler dan metabolik. Kadar laktat dan albumin serum terbukti berpengaruh terhadap perjalanan sepsis. Tujuan: Menilai laktat, albumin dan rasio laktat albumin sebagai prediktor luaran sepsis dan syok septik. Metode: Penelitian cross-sectional ini menggunakan data rekam medik periode Januari 2017 – April 2019. Uji statistik yang digunakan adalah uji Fisher, uji-t tidak berpasangan, uji Mann-Whitney dan uji korelasi Spearman. Hasil uji signifikan jika p<0,05. Kurva ROC untuk menentukan cut-off dan Kurva Kaplan Meier untuk menggambarkan survival time. Hasil: Analisis kurva ROC, menunjukkan AUC laktat dan rasio laktat albumin dalam memprediksi syok septik (0,636 dan 0,634) dengan cut-off laktat 1,95 mmol/L (sensitivitas 82%, spesifisitas 32%) dan rasio laktat albumin 0,81 (sensitivitas 82%, spesifisitas 39%). Tidak terdapat hubungan signifikan antara laktat, albumin dan rasio laktat albumin terhadap luaran (p=0,184, p=0,595, p=0,102). Terdapat korelasi negatif dengan kekuatan korelasi lemah antara kadar laktat dan rasio laktat albumin dengan survival time. Simpulan: Laktat dan rasio laktat albumin dapat dijadikan sebagai biomarker untuk memprediksi terjadinya syok septik, namun tidak dapat dijadikan sebagai prediktor luaran pada sepsis dan syok septik.Kata kunci: rasio laktat albumin, sepsis, syok septik
Blood transfusion is an important part of health care. A blood transfusion can be carried out after careful consideration of its risks and benefits. One of the important considerations for blood transfusion is adverse transfusion reaction. Several risk factors for a transfusion reaction are age, gender, repeated transfusion, disease diagnosis, type of blood component, and blood incompatibility. This research is a descriptive study performed at Blood Bank Dr. Wahidin Sudirohusodo Hospital, Makassar, from January to December 2017. The subjects were all patients reported to have an acute transfusion, totaling 104 subjects. The descriptive method was carried out by the calculation of frequency distribution. From January to December 2017, 104 patients with transfusion reactions were obtained, predominantly were male (53.8%), with the lowest age range of ≥ 60 years (27.9%), packed red cell as the most found blood components (82.4%), a history of previous transfusion reactions (72.1%), and a diagnosis of malignancy (53.9%). The history of repeated transfusions is the most common risk factor compared to age, gender, blood component, and patient diagnosis.
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