An autopsy case of primary hepatic fibrosarcoma with severe hypoglycemia is reported. Only two cases have been previously reported. Histological features were well differentiated and partly indistinguishable from those of fibrous mesothelioma. ACTA PATHOL. JPN. 33 : 177-182, 1983.
Nephrotoxic activity of rabbit antisera to glomerular basement membrane (GBM) from three different donors (rat, gerbil, and man) was examined in mice of various strains. Animals receiving a small dose (0.1 ml) of anti-rat GBM or a large dose (0.3 mlx2) of anti-gerbil GBM developed massive proteinuria and irreversible glomerular lesions which were identical to those seen in rats receiving anti-rat GBM, i.e. rat Masugi nephritis. Linear deposition of rabbit IgG, host's immunoglobulins and C3 was characteristically seen. Necrotizing changes and crescent formation accompanied by plasmic exudation, cellular proliferation and/or infiltration of PMNs and monocytes occurred after the injection. In animals receiving anti-human GBM, linear deposition of rabbit IgG and less marked glomerular changes were seen. The finding of no specificity in species between GBM antigens of rat and mouse indicates the usefulness of rat GBM for mouse Masugi nephritis or anti-GBM disease. ACTA PATHOL. JPN. 31: 85-92, 1981.
Three Japanese patients with von Recklinghausen's disease and malignant changes were studied. The primary lesions of malignant changes were the chest wall in Case 1, the buttock in Case 2, and the neck in Case 3. After excision of the tumors, there were local recurrences in Cases 1 and 2. Distant metastases developed during treatment in these patients. One of the patients (Case 1) died 21 months after the initial diagnosis of malignancy. Multidisciplinary treatment was of some value in suppressing local recurrences and pulmonary metastases in Case 2. Pulmonary metastases were evident at the time of admission to our hospital in Case 3. Although the primary and metastatic tumors were removed, the patient died 8 months after the initial diagnosis of malignancy. We conclude that careful follow-up should be required in patients with von Recklinghausen's disease because of the possibility of malignant changes. When there is a suspicion of malignancy, an extended en-block excision must be performed.
We studied the effect of cyclophosphamide (CPM) on development of severe glomerular lesions in a model of murine nephrotoxic nephritis (NTN). CPM treatment (300 mg/kg) before initiation of the first phase on NTN showed no host antibody depositions along the glomerular basement membrane, as revealed by immunofíuorescence; however, the histological study revealed no significant difference in the degree of renal damage between the control and the CPM-treated mice. Therefore, the severe glomerular lesions in murine NTN may be induced without antibody response to nephrotoxin, in the glomerulus.
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