In this non-controlled open trial bupropion 150 mg/daily was associated with improved sexual function in women receiving adjuvant systemic treatment for breast cancer.

Key Points Question What are the efficacy and safety associated with immune checkpoint inhibitors (ICIs) vs standard therapies in unresectable hepatocellular carcinoma (HCC)? Findings In a meta-analysis of 3 randomized clinical trials totaling 1657 patients, ICIs were associated with significantly improved overall survival, progression-free survival, and overall response rate compared with standard therapies. In addition, the rate of grade 3 or 4 treatment-related adverse events was lower with ICIs than with sorafenib. Meaning These findings suggest that ICIs should be the new standard of care in systemic therapy of unresectable HCC.

In this large retrospective study, the standard prognostic factors impacted on survival whereas the timing of adjuvant therapy did not. Patients with delayed adjuvant chemotherapy may have worse prognostic factors which could play a major role in their poor outcome.

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Gastric cancer is among the ten most common types of cancer worldwide. Most cases and deaths related to the disease occur in developing countries. Local socioeconomic , epidemiologic and healthcare particularities led us to create a Brazilian guideline for the management of gastric carcinomas. The Brazilian Group of Gastrointestinal Tumors (GTG) invited 50 physicians with different backgrounds, including radiology, pathology, endoscopy, nuclear medicine, genetics, oncological surgery, radiotherapy and clinical oncology, to collaborate. This document was prepared based on an extensive review of topics related to heredity,