The synthesis of a series of 5‐ and 6‐substituted 4‐trihalomethyl‐2‐methylthiopyrimidines, prepared from the cyclocondensation reaction of β‐alkoxyvinyl tri[fluoro]chloromethyl ketones with 2‐methyl‐2‐thiopseudourea sulfate, are reported. A systematic study to find the best reaction conditions were carried out.
Haloacetylated Enol Ethers. Part 4. Synthesis of 4-Trihalomethyl-2methylthiopyrimidines.-A series of title compounds such as (III) and (V) is obtained by cyclocondensation of β-alkoxyvinyl ketones such as (I) with the urea derivative (II). It is noteworthy that in cases where the double bond of (I) is incorporated in a ring system none of the studied reaction conditions leads to a desired product. -(MADRUGA, C. C.; CLERICI, E.; MARTINS, M. A. P.; ZANATTA, N.; J. Heterocycl. Chem. 32 (1995) 3, 735-738; Dep. Quim., Univ. Fed., 97. 119-900 Santa Maria, RS, Brazil; EN)
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