Chronic kidney disease (CKD) is among the top 20 causes of death worldwide and affects approximately 10% of the world adult population. CKD is a disorder that disrupts normal kidney function. Due to the increasing number of people with CKD, effective prediction measures for the early diagnosis of CKD are required. The novelty of this study lies in developing the diagnosis system to detect chronic kidney diseases. This study assists experts in exploring preventive measures for CKD through early diagnosis using machine learning techniques. This study focused on evaluating a dataset collected from 400 patients containing 24 features. The mean and mode statistical analysis methods were used to replace the missing numerical and the nominal values. To choose the most important features, Recursive Feature Elimination (RFE) was applied. Four classification algorithms applied in this study were support vector machine (SVM), k-nearest neighbors (KNN), decision tree, and random forest. All the classification algorithms achieved promising performance. The random forest algorithm outperformed all other applied algorithms, reaching an accuracy, precision, recall, and F1-score of 100% for all measures. CKD is a serious life-threatening disease, with high rates of morbidity and mortality. Therefore, artificial intelligence techniques are of great importance in the early detection of CKD. These techniques are supportive of experts and doctors in early diagnosis to avoid developing kidney failure.

With the increasing incidence of severe skin diseases, such as skin cancer, endoscopic medical imaging has become urgent for revealing the internal and hidden tissues under the skin. Diagnostic information to help doctors make an accurate diagnosis is provided by endoscopy devices. Nonetheless, most skin diseases have similar features, which make it challenging for dermatologists to diagnose patients accurately. Therefore, machine and deep learning techniques can have a critical role in diagnosing dermatoscopy images and in the accurate early detection of skin diseases. In this study, systems for the early detection of skin lesions were developed. The performance of the machine learning and deep learning was evaluated on two datasets (e.g., the International Skin Imaging Collaboration (ISIC 2018) and Pedro Hispano (PH2)). First, the proposed system was based on hybrid features that were extracted by three algorithms: local binary pattern (LBP), gray level co-occurrence matrix (GLCM), and wavelet transform (DWT). Such features were then integrated into a feature vector and classified using artificial neural network (ANN) and feedforward neural network (FFNN) classifiers. The FFNN and ANN classifiers achieved superior results compared to the other methods. Accuracy rates of 95.24% for diagnosing the ISIC 2018 dataset and 97.91% for diagnosing the PH2 dataset were achieved using the FFNN algorithm. Second, convolutional neural networks (CNNs) (e.g., ResNet-50 and AlexNet models) were applied to diagnose skin diseases using the transfer learning method. It was found that the ResNet-50 model fared better than AlexNet. Accuracy rates of 90% for diagnosing the ISIC 2018 dataset and 95.8% for the PH2 dataset were reached using the ResNet-50 model.

Eye tracking is a useful technique for detecting autism spectrum disorder (ASD). One of the most important aspects of good learning is the ability to have atypical visual attention. The eye-tracking technique provides useful information about children’s visual behaviour for early and accurate diagnosis. It works by scanning the paths of the eyes to extract a sequence of eye projection points on the image to analyse the behaviour of children with autism. In this study, three artificial-intelligence techniques were developed, namely, machine learning, deep learning, and a hybrid technique between them, for early diagnosis of autism. The first technique, neural networks [feedforward neural networks (FFNNs) and artificial neural networks (ANNs)], is based on feature classification extracted by a hybrid method between local binary pattern (LBP) and grey level co-occurrence matrix (GLCM) algorithms. This technique achieved a high accuracy of 99.8% for FFNNs and ANNs. The second technique used a pre-trained convolutional neural network (CNN) model, such as GoogleNet and ResNet-18, on the basis of deep feature map extraction. The GoogleNet and ResNet-18 models achieved high performances of 93.6% and 97.6%, respectively. The third technique used the hybrid method between deep learning (GoogleNet and ResNet-18) and machine learning (SVM), called GoogleNet + SVM and ResNet-18 + SVM. This technique depends on two blocks. The first block used CNN to extract deep feature maps, whilst the second block used SVM to classify the features extracted from the first block. This technique proved its high diagnostic ability, achieving accuracies of 95.5% and 94.5% for GoogleNet + SVM and ResNet-18 + SVM, respectively.

Dementia and Alzheimer’s disease are caused by neurodegeneration and poor communication between neurons in the brain. So far, no effective medications have been discovered for dementia and Alzheimer’s disease. Thus, early diagnosis is necessary to avoid the development of these diseases. In this study, efficient machine learning algorithms were assessed to evaluate the Open Access Series of Imaging Studies (OASIS) dataset for dementia diagnosis. Two CNN models (AlexNet and ResNet-50) and hybrid techniques between deep learning and machine learning (AlexNet+SVM and ResNet-50+SVM) were also evaluated for the diagnosis of Alzheimer’s disease. For the OASIS dataset, we balanced the dataset, replaced the missing values, and applied the t-Distributed Stochastic Neighbour Embedding algorithm (t-SNE) to represent the high-dimensional data in the low-dimensional space. All of the machine learning algorithms, namely, Support Vector Machine (SVM), Decision Tree, Random Forest and K Nearest Neighbours (KNN), achieved high performance for diagnosing dementia. The random forest algorithm achieved an overall accuracy of 94% and precision, recall and F1 scores of 93%, 98% and 96%, respectively. The second dataset, the MRI image dataset, was evaluated by AlexNet and ResNet-50 models and AlexNet+SVM and ResNet-50+SVM hybrid techniques. All models achieved high performance, but the performance of the hybrid methods between deep learning and machine learning was better than that of the deep learning models. The AlexNet+SVM hybrid model achieved accuracy, sensitivity, specificity and AUC scores of 94.8%, 93%, 97.75% and 99.70%, respectively.

Cardiovascular disease (CVD) is one of the most common causes of death that kills approximately 17 million people annually. The main reasons behind CVD are myocardial infarction and the failure of the heart to pump blood normally. Doctors could diagnose heart failure (HF) through electronic medical records on the basis of patient’s symptoms and clinical laboratory investigations. However, accurate diagnosis of HF requires medical resources and expert practitioners that are not always available, thus making the diagnosing challengeable. Therefore, predicting the patients’ condition by using machine learning algorithms is a necessity to save time and efforts. This paper proposed a machine-learning-based approach that distinguishes the most important correlated features amongst patients’ electronic clinical records. The SelectKBest function was applied with chi-squared statistical method to determine the most important features, and then feature engineering method has been applied to create new features correlated strongly in order to train machine learning models and obtain promising results. Optimised hyperparameter classification algorithms SVM, KNN, Decision Tree, Random Forest, and Logistic Regression were used to train two different datasets. The first dataset, called Cleveland, consisted of 303 records. The second dataset, which was used for predicting HF, consisted of 299 records. Experimental results showed that the Random Forest algorithm achieved accuracy, precision, recall, and F1 scores of 95%, 97.62%, 95.35%, and 96.47%, respectively, during the test phase for the second dataset. The same algorithm achieved accuracy scores of 100% for the first dataset and 97.68% for the second dataset, while 100% precision, recall, and F1 scores were reached for both datasets.