Laboratory findings obtained at the initial examination may be helpful in predicting a fatal or chronic course of AN. An evaluation of the long-term outcome of eating disorders should include an assessment of the medical co-morbidity.

Selected examples from man and canine experiments with time series of reticular neurons, respiration, arterial blood pressure, and cutaneous forehead blood content fluctuations were analyzed using multiscaled Time-Frequency-Distribution (TFD), Post-Event-Scan (PES), and Pointwise Transinformation (PTI), resp.. We found in both experiments a "0.15 Hz rhythm" which exhibited periods of spindle wave epochs (increasing and decreasing amplitudes) to be phase synchronized with respiration at 1:2, 1:1 and 2:1 integer number ratios. At times of these wave-epochs and n:m phase-synchronization, the "0.15 Hz rhythm" appeared also in heart rate and arterial blood pressure fluctuations. If phase synchronization of the "0.15 Hz rhythm" with respiration was established at a 1:1 integer number ratio, it was maintained throughout and resulted in consensualization of all cardio-vascular-respiratory oscillations at 0.15 Hz. Analysis of a canine experiment supplied evidence that the emergence of the "0.15Hz rhythm" and n:m phase synchronization appears to result from a decline in the level of the general activity of the organism which was associated with a decline in the level of activity of reticular neurons in the lower brainstem network. These findings corroborate the notion of the "0.15 Hz rhythm" to be a state marker of the `trophotropic mode of operation` which was introduced by W.R. Hess.